TRACING COLLATERAL CIRCULATION AFTER ISCHEMIA IN RAT CORTEX BY LASER SPECKLE IMAGING  

作　　者：WEIHUA LUO PENGCHENG LI ZHEN WANG SHAOQUN ZENG QINGMING LUO 

机构地区：[1]Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074,China

出　　处：《Journal of Innovative Optical Health Sciences》2008年第2期217-226,共10页创新光学健康科学杂志（英文）

基　　金：supported by the National High Technology Research and Development Program of China(Grant No.2007AA022303);the National Natural Science Foundation of China(Grant No.30500115);the NSFC-FBR International Joint Research Project(Grant No.30711120171);the Program for Changjiang Scholars and Innovative Research Team in University.

摘　　要：The collateral circulation is crucial for the pathophysiology and outcome of acute cortical ischemia.Current understanding of collateral circulation still remains sparse,largely due to prior limitations of spatial or/and temporal resolution in methods to evaluate these diminutive redistributive routes of cerebral blood flow(CBF)especially in leptomeningeal anastomoses that connected cortical arteries.In the study,based on a mini-stroke model,laser speckle imaging with high spatiotemporal resolution was used to assess the dynamic evolution of the collateral circulation around a mini-ischemia in the rat cortex.We found that the blood flow and diameter in the intra-arterial anastomoses were enhanced immediately after the ligation of one branch of middle cerebral artery and recovered to baseline level as arterial recirculation was performed.Whereas the communicative flow-through of the posterior cerebral artery and the middle cerebral artery anastomoses was not significant enough to be determined.This is the evidence that intra-arterial anastomoses were the primary routes to restore blood flow into the ischemic territory during the acute phase of ischemia,and laser speckle imaging method was proven as a powerful tool to be potential for subserving further investigation of the collateral circulation.

关 键 词：Cerebral blood flow ANASTOMOSES mini-stroke model 

分 类 号：R74[医药卫生—神经病学与精神病学]