Tetrahydropalmatine attenuates liver fibrosis by suppressing endoplasmic reticulum stress in hepatic stellate cells  

作　　者：Yuanyuan Xuan Shiyun Chen Xin Ding Lexun Wang Shengwen Li Guizhi Yang Tian Lan 

机构地区：[1]Institute of Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou,Guangdong 510006,China [2]School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou,Guangdong 510006,China [3]Clinical Medicine,Guangdong Pharmaceutical University,Guangzhou,Guangdong 510006,China [4]Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine,Guangzhou,Guangdong 510006,China

出　　处：《Chinese Medical Journal》2022年第5期628-630,共3页中华医学杂志（英文版）

基　　金：National Natural Science Foundation of China (No. 81870420)。

摘　　要：To the Editor: Liver fibrosis was characterized by the activation of hepatic stellate cells (HSCs) and extracellular matrix deposition. The pathogenesis of liver fibrosis involved many aspects. Studies have found that endoplasmic reticulum stress (ERS) in HSCs could lead to HSC activation and aggravate liver fibrosis.[1] Although liver fibrosis has been extensively studied, effective anti-fibrotic drugs are lacking at present. Tetrahydropalmatine (THP) was the active ingredient of Chinese herbs Corydalis yanhusuo. Previous studies have found the hepatoprotective effect of THP. Our study aimed to investigate the effects of THP on liver fibrosis and the underlying mechanisms.

关 键 词：HEPATIC reticulum protective 

分 类 号：R575.2[医药卫生—消化系统]