小儿疱疹病毒感染252例临床分析  

Clinical analysis of 252 children with Epstein-Barr virus infection

作　　者：王璐 王璁 林洪云 胥苗林 Wang Lu;Wang Cong;Lin Hongyun;Xu Miaolin(Department of Pharmacy,Liaocheng Maternal and Child Health Hospital,Liaocheng 252000,Shandong Province,China;Department of Pediatrics,Liaocheng Maternal and Child Health Hospital,Liaocheng 252000,Shandong Province,China)

机构地区：[1]聊城市妇幼保健院药剂科,聊城252000 [2]聊城市妇幼保健院儿科,聊城252000

出　　处：《中国基层医药》2022年第4期526-529,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨小儿疱疹病毒(EBV)感染的临床表现及干扰素联合更昔洛韦治疗的疗效。方法选取2018年6月至2020年2月在聊城市妇幼保健院诊治的EB病毒感染患儿252例,采用随机数字表法分为对照组和实验组各126例,对照组采用更昔洛韦单独治疗,实验组采用干扰素、更昔洛韦联合治疗。对两组患儿的一般情况、临床表现以及治疗效果进行分析。结果该研究252例EBV病毒感染患儿中,按照年龄分组:婴儿期3.97%、幼儿期53.57%、学龄前期28.97%、学龄期13.49%,幼儿期和学龄前期所占比例较高;临床主要以发热、咽充血、颈部淋巴结肿大、咽痛为主要表现,其中肝脾肿大在学龄期(44.12%)所占比例最高,双眼水肿在幼儿期(10.37%)所占比例最高。实验组热退时间、眼睑水肿及淋巴结肿大消退时间分别为(3.55±1.58)h、(3.82±1.17)h、(9.55±1.60)h,均明显短于对照组的(4.40±1.80)h、(5.33±1.58)h、(10.44±1.66)h(t=3.64、2.47、2.67,P<0.001、P=0.024、0.009)。实验组总有效率为96.03%(107/126)明显高于对照组的84.92%(121/126),两组总有效率差异有统计学意义(χ^(2)=9.03,P=0.003)。结论儿童EBV感染在不同年龄组的临床表现多样,治疗上采用干扰素联合更昔洛韦效果更显著。Objective To investigate the clinical manifestations of Epstein-Barr virus infection in children and the efficacy of interferon combined with ganciclovir.Methods A total of 252 children with Epstein-Barr virus infection who received treatment in Liaocheng Maternal and Child Health Hospital from June 2018 to February 2020 were included in this study.They were randomly assigned to undergo treatment either with ganciclovir alone(control group,n=126)or interferon combined with ganciclovir(experimental group,n=126).General condition,clinical manifestation,clinical outcomes,and clinical efficacy were compared between the two groups.Results The 252 children with Epstein-Barr virus infection were divided into four groups according to different age brackets:infancy(3.97%),early childhood(53.57%),preschool(28.97%),school age(13.49%).Children at the early childhood and preschool ages accounted for high proportions.Their clinical manifestations included fever,pharyngeal congestion,cervical lymph node swelling,and pharyngeal pain.Children with hepatosplenomegaly accounted for the highest proportion(44.12%)among those at the school age,and children with binocular edema accounted for the highest proportion(10.37%)among those at the early childhood age.The time to defervesce,eyelid edema,and lymph node regression in the experimental group were(3.55±1.58)hours,(3.82±1.17)hours,and(9.55±1.60)hours respectively,which were significantly shorter than those in the control group[(4.40±1.80)hours,(5.33±1.58)hours,(10.44±1.66)hours,t=3.64,2.47,2.67,P<0.001,P=0.024,0.009].The total response rate was significantly higher in the experimental group than in the control group[96.03%(107/126)vs.84.92%(121/126),χ^(2)=9.03,P=0.003].Conclusion Epstein-Barr virus infection has different clinical manifestations in children at different ages.Interferon combined with ganciclovir is more effective on Epstein-Barr virus infection than ganciclovir alone.

关 键 词：疱疹病毒 更昔洛韦 干扰素 发热 咽充血 颈部淋巴结肿大 咽痛 双眼水肿 肝脾肿大 

分 类 号：R725.1[医药卫生—儿科]