The contradictory role of androgens in cutaneous and major burn wound healing  

作　　者：Huaikai Shi Kenny Cheer Ulla Simanainen Brian Lesmana Duncan Ma Jonathan J.Hew Roxanne J.Parungao Zhe Li Mark S.Cooper David J.Handelsman Peter K.Maitz Yiwei Wang 

机构地区：[1]Burns Research Group,ANZAC Research Institute,University of Sydney,Concord Hospital,Gate,3 Hospital road,Concord,NSW 2139,Australia [2]Andrology,ANZAC Research Institute,University of Sydney,Concord Hospital,Gate,3 Hospital road,Concord,NSW 2139,Australia [3]Adrenal Steroid Laboratory,ANZAC Research Institute,University of Sydney,Concord Hospital,Gate,3 Hospital road,Concord,NSW 2139,Australia [4]Burns and Reconstructive Surgery Unit,Concord Hospital,Gate,3 Hospital road,Concord,NSW 2139,Australia

出　　处：《Burns & Trauma》2021年第1期545-557,共13页烧伤与创伤（英文）

摘　　要：Wound healing is a complex process involving four overlapping phases:haemostasis,inflammation,cell recruitment and matrix remodeling.In mouse models,surgical,pharmacological and genetic approaches targeting androgen actions in skin have shown that androgens increase interleukin-6 and tumor necrosis factor-αproduction and reduce wound re-epithelization and matrix deposition,retarding cutaneous wound healing.Similarly,clinical studies have shown that cutaneous wound healing is slower in men compared to women.However,in major burn injury,which triggers not only local wound-healing processes but also systemic hypermetabolism,the role of androgens is poorly understood.Recent studies have claimed that a synthetic androgen,oxandrolone,increases protein synthesis,improves lean body mass and shortens length of hospital stay.However,the possible mechanisms by which oxandrolone regulates major burn injury have not been reported.In this review,we summarize the current findings on the roles of androgens in cutaneous and major burn wound healing,as well as androgens as a potential therapeutic treatment option for patients with major burn injuries.

关 键 词：Wound healing ANDROGEN Mouse model Oxandrolone Cutaneous injury Major burn injury 

分 类 号：F42[经济管理—产业经济]