无托槽隐形矫治青少年患者唾液中趋化因子水平与龋白斑的相关性研究  

The correlation between chemokine levels in saliva and caries leukoplakia in adolescent patients receiving invisible orthodontic treatment

作　　者：骆厚卓 方世殊 宋致馨 金作林 刘倩 LUO Houzhuo;FANG Shishu;SONG Zhixin;JIN Zuolin;LIU Qian(State Key Laboratory of Military Stomatology&National Clinical Research Center for Oral Diseases&Shaanxi Clinical Research Center for Oral Diseases,Department of Orthodontics,School of Stomatology,The Fourth Military Medical University,China,Xi'an 710032)

机构地区：[1]军事口腔医学国家重点实验室,国家口腔疾病临床医学研究中心,陕西省口腔疾病临床医学研究中心,第四军医大学口腔医院正畸科,西安710032

出　　处：《实用口腔医学杂志》2022年第2期229-233,共5页Journal of Practical Stomatology

基　　金：国家口腔疾病临床医学研究中心资助项目(编号:LCA202009)。

摘　　要：目的:探究接受无托槽隐形矫治的青少年患者唾液中趋化因子CXCL8、CXCL10、CXCL11和CXCL13的表达水平与龋白斑发生的相关性。方法:纳入接受隐形矫治6个月以上的青少年患者78例,根据患者是否发生龋白斑划分为无龋白斑组(n=46)和龋白斑组(n=32),分析患者口腔一般情况,并检测唾液中趋化因子CXCL8、CXCL10、CXCL11和CXCL13的表达水平。结果:无龋白斑组与龋白斑组患者一般情况无统计学差异(P>0.05);龋白斑组患者唾液中CXCL10、CXCL11和CXCL13的表达水平均显著高于无龋白斑组患者(P<0.05),CXCL8表达水平在两组中无明显差异(P>0.05)。二元Logistic回归方程分析表明患者唾液中CXCL10表达水平(OR=1.156)、CXCL11表达水平(OR=1.099)和CXCL13表达水平(OR=1.126)与发生龋白斑具有显著相关性。结论:接受无托槽隐形矫治青少年患者龋白斑的发生与CXCL10、CXCL11和CXCL13的表达水平具有显著相关性。Objective:To investigate the correlation between the saliva expression levels of CXCL8,CXCL10,CXCL11,CXCL13 and the occurrence of caries leukoplakia in adolescent patients receiving invisible orthodontic therapy without bracket.Methods:78 adolescent patients underwent invisible orthodontic therapy without bracket for more than 6 months were divided into caries leucoplakia group(CL)(n=32)and non-CL group(n=46).The expression levels of CXCL8,CXCL10,CXCL11 and CXCL13 in saliva were compared between the 2 groups.Results:There was no significant difference in the general data between the 2 groups(P>0.05).The expression levels of CXCL10,CXCL11 and CXCL13 in saliva of patients in CL group were higher than those in non-CL group(P<0.05)and there was no significant difference in CXCL8 expression between the 2 groups P>0.05).Binary Logistic regression analysis showed that the expression levels of CXCL10(OR=1.156),CXCL11(OR=1.099)and CXCL13(OR=1.126)in saliva of patients were significantly correlated with the occurrence of caries leukoplakia in patients.Conclusion:The chemokines CXCL10,CXCL11and CXCL13 may be related to the occurrence of caries leukoplakia in adolescent patients undergoing invisible orthodontic therapy.

关 键 词：无托槽隐形矫治 龋白斑 趋化因子 正畸菌斑指数 

分 类 号：R783.5[医药卫生—口腔医学]