雷贝拉唑联合莫沙必利治疗老年反流性食管炎患者的效果及对胃肠激素、氧自由基水平的影响  

Effect of rabeprazole combined with mosapride in the treatment of elderly patients with reflux esophagitis and its influences on the levels of gastrointestinal hormones and oxygen free radicals

作　　者：曹娟 谢旭东 CAO Juan;XIE Xudong(People's Hospital of Tongchuan,Tongchuan 727000,China)

机构地区：[1]铜川市人民医院,陕西铜川727000

出　　处：《临床医学研究与实践》2022年第11期39-42,共4页Clinical Research and Practice

摘　　要：目的探讨雷贝拉唑联合莫沙必利治疗老年反流性食管炎(RE)患者的效果及对胃肠激素、氧自由基水平的影响。方法择取2018年9月至2020年10月我院收治的120例RE患者为研究对象,按照治疗方案将其分为对照组和观察组,各60例。对照组给予莫沙必利治疗,观察组在对照组治疗方案基础上加施雷贝拉唑。比较两组的临床疗效及治疗前、后的胃肠激素、氧自由基及食欲调节因子水平。结果观察组的治疗总有效率为95.00%,高于对照组的83.33%高(P<0.05)。治疗后,观察组的GAS、MTL水平高于对照组,VIP、SS水平低于对照组(P<0.05)。治疗后,观察组的SOD、T-AOC水平高于对照组,MDA水平低于对照组(P<0.05)。治疗后,观察组的NPY、Ghrelin水平高于对照组,Leptin水平低于对照组(P<0.05)。结论雷贝拉唑联合莫沙必利用于老年RE患者中的效果满意,可有效调节机体胃肠激素,改善氧自由基及食欲调节因子水平,值得推广应用。Objective To explore the effect of rabeprazole combined with mosapride in the treatment of elderly patients with reflux esophagitis(RE)and its influences on the levels of gastrointestinal hormones and oxygen free radicals.Methods A total of 120 RE patients admitted in our hospital from September 2018 to October 2020 were selected as the research objects.According to the treatment plan,the patients were divided into control group and observation group,with 60 cases in each group.The control group was given mosapride treatment,and the observation group was given rabeprazole on the basis of the treatment plan of the control group.The clinical efficacy and levels of gastrointestinal hormones,oxygen free radicals and appetite regulator before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.00%,which was higher than 83.33%in the control group(P<0.05).After treatment,the GAS and MTL levels of the observation group were higher than those of the control group,and the VIP and SS levels were lower than those of the control group(P<0.05).After treatment,the SOD and T-AOC levels of the observation group were higher than those of the control group,and the MDA level was lower than that of the control group(P<0.05).After treatment,the NPY and Ghrelin levels of the observation group were higher than those of the control group,and the Leptin level was lower than that of the control group(P<0.05).Conclusion Rabeprazole combined with mosapride used in elderly patients with RE has a satisfactory effect.It can effectively regulate the body's gastrointestinal hormones,and improve the levels of oxygen free radicals and appetite regulator,which is worthy of popularization and application.

关 键 词：雷贝拉唑 莫沙必利 反流性食管炎 胃肠激素 氧自由基 食欲调节因子 

分 类 号：R571[医药卫生—消化系统]