病原感染在自身免疫性肝病发生发展中的作用  

The role of pathogen infections in the development and progression of autoimmune liver diseases

作　　者：张海萍[1] 闫惠平[1] 陈德喜[1] 马迎民 ZHANG Haiping;YAN Huiping;CHEN Dexi;MA Yingmin(Center of Clinical Laboratory,Beijing YouAn Hospital,Capital Medical University&Beijing Institute of Hepatology,Beijing 100069,China)

机构地区：[1]首都医科大学附属北京佑安医院临检中心,北京市肝病研究所,北京100069

出　　处：《临床肝胆病杂志》2022年第4期754-758,共5页Journal of Clinical Hepatology

基　　金：北京市属医学科研院所公益发展改革试点项目(京医研2021-10);首都医科大学附属北京佑安医院2021年院内中青年人才孵育项目(青年创新类)(YNKTQN2021004)。

摘　　要：自身免疫性肝病(AILD)的病因和发病机制研究一直是领域内的研究热点。病原体感染可参与诱发机体的自身免疫反应,常常成为免疫性疾病的关键致病因素。本文基于文献数据和作者临床经验,将从分子模拟机制等方面对病原感染在AILD的发生和发展中的作用及其影响进行简单介绍,以助更深入地了解AILD的发病机制。The etiology and pathogenesis of autoimmune liver diseases has always been a hot area of research.Pathogen infections can elicit an autoimmune response and often become the key pathogenic factor of immune diseases.Based on the literature data and the author’s clinical experience,this review will briefly introduce the role and influence of pathogen infections in the development and progression of autoimmune liver diseases from the aspects such as molecular mimicry mechanism,in order to further understand the pathogenesis of autoimmune liver diseases.

关 键 词：病原 自身免疫性肝病 分子模拟 病理过程 

分 类 号：R575[医药卫生—消化系统]