肠道菌群及其代谢物在胆囊胆固醇结石形成中的作用机制  

The mechanism of intestinal flora and its metabolites in the formation of cholesterol gallstones

作　　者：赵瀚东 高鹏[2] 詹丽[3] ZHAO Handong;GAO Peng;ZHAN Li(The First Clinical Medical College of Gansu University of Chinese Medicine&Gansu Provincial Hospital,Lanzhou 730000,China;Department of General Surgery,Gansu Provincial People’s Hospital,Lanzhou 730000,China;Department of Gastroenterology,Gansu Provincial People’s Hospital,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学第一临床医学院(甘肃省人民医院),兰州730000 [2]甘肃省人民医院普外科,兰州730000 [3]甘肃省人民医院消化科,兰州730000

出　　处：《临床肝胆病杂志》2022年第4期947-950,共4页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81660398)。

摘　　要：胆囊结石是一种常见的多因素参与的消化系统疾病,80%以上为胆固醇结石,其发病率逐年增加。近年来研究发现肠道菌群参与胆囊胆固醇结石的发生发展。从肠道菌群及其代谢物对胆汁酸调控方面,阐述了肠道菌群及其代谢物在胆囊胆固醇结石发展中的作用,指出未来针对肠道菌群及其代谢产物的干预策略可能是预防和治疗胆囊胆固醇结石的新靶点。Gallstone is a common digestive system disease involving multiple factors,more than 80%of which are cholesterol gallstones,and its incidence rate is increasing year by year.Recent studies have shown that intestinal flora is involved in the development and progression of cholesterol gallstones.This article elaborates on the role of intestinal flora and its metabolites in the progression of cholesterol gallstones from the aspect of regulation of bile acids by intestinal flora and its metabolites,and it is pointed out that intervention strategies for intestinal flora and its metabolites may be a new target for the prevention and treatment of cholesterol gallstones in the future.

关 键 词：胃肠道微生物组 胆结石 肠肝循环 胆汁酸 

分 类 号：R575.62[医药卫生—消化系统]