巨噬细胞在肺癌转移中的作用  

The role of macrophages in metastasis of lung cancer

作　　者：于盼 周奕阳[1] 罗斌[1,2] 许帆 田建辉[1,2,3] Pan Yu;Yiyang Zhou;Bin Luo;Fan Xu;Jianhui Tian(Cancer Clinical Medical Center,Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China;Department of Oncology,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Oncology Institute of Traditional Chinese Medicine,Shanghai Academy of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属市中医医院肿瘤临床医学中心,上海市200071 [2]上海中医药大学附属龙华医院肿瘤科 [3]上海市中医药研究院中医肿瘤研究所

出　　处：《中国肿瘤临床》2022年第6期299-303,共5页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金项目(编号:81973517,81774166);上海市科技英才扬帆计划项目(编号:20YF1449900)赞助。

摘　　要：转移是导致肺癌患者死亡的关键临床事件,目前针对转移高发人群仍缺乏有效的筛选与诊疗手段。免疫治疗显著提高晚期肺癌疗效,提示其有望突破肺癌转移防治的瓶颈。巨噬细胞作为固有免疫的重要组成部分,在肿瘤的发生与转移过程中发挥着重要作用,有望从固有免疫角度丰富肿瘤免疫治疗的手段。在肿瘤发生发展的不同阶段,巨噬细胞在机体的不同器官被肿瘤细胞驯化出不同的“状态”而有利于肿瘤的发展与转移。因此,靶向巨噬细胞防治肺癌转移成为肿瘤免疫治疗的新策略。靶向巨噬细胞的增殖、招募、极化、血管生成和免疫抑制等阶段,开发单克隆抗体及小分子抑制剂是抗肺癌转移新药研发的趋势。Metastasis is a crucial clinical event leading to mortality in patients with lung cancer.Effective screening,diagnosis,and treatment are still lacking for people with a high incidence of metastasis.The demonstrated significant effect of immunotherapy in the treatment of lung cancer indicates the potential of this strategy in the prevention and treatment of metastases.As an important part of innate immunity,macrophages are important in the occurrence and metastasis of tumors.The use of macrophages might improve tumor immunotherapy from the perspective of innate immunity.At different stages of tumorigenesis and development,macrophages are domesticated into different“states”by tumor cells in various organs of the body,which is beneficial for the development and metastasis of tumors.Therefore,targeted macrophage prevention and treatment of lung cancer metastasis has become a new strategy for tumor immunotherapy.The development of monoclonal antibodies and small molecule inhibitors targeting macrophage proliferation,recruitment,polarization,angiogenesis,and immunosuppression is an important aspect of research and development of new drugs against lung cancer metastasis.

关 键 词：巨噬细胞 肺癌 转移 固有免疫 免疫治疗 

分 类 号：R734.2[医药卫生—肿瘤]