IL-33与疼痛关系的回顾与展望  

A review of the relationship between IL-33 and pain and prospect

作　　者：汪逸纯 张真真[2] 万贵平[2] WANG Yichun;ZHANG Zhenzhen;WAN Guiping(Affiliated Hospital ofIntegrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Jiangsu,Nanjing 210000,China;Jiangsu Province Hospital on Integration of Chinese and Western Medicine,Jiangsu,Nanjing 210000,China)

机构地区：[1]南京中医药大学附属中西医结合医院,江苏南京210000 [2]江苏省中西医结合医院,江苏南京210000

出　　处：《中国医药科学》2022年第6期41-43,81,共4页China Medicine And Pharmacy

基　　金：江苏省教育厅研究生创新实践计划(SJCX21-0797)。

摘　　要：白细胞介素-33(IL-33)作为白细胞介素-1细胞因子超家族的新成员,在各种疼痛反应过程中发挥调节作用。通过回顾炎症性疼痛、神经性疼痛、骨癌痛、手臂振动综合征、疼痛性膀胱综合征以及急性心肌梗死等疾病文献中的IL-33含量,发现IL-33在不同组织、系统中存在表达差异,且IL-33可诱导生长刺激表达基因2蛋白(ST2)受体广泛表达(尤其是辅助性T2细胞和肥大细胞),以核因子κB(NF-κB)依赖的方式产生促炎性物质,释放信号因子,促进下游通路中炎症反应的发生,进而参与T细胞介导的免疫应答,这为疼痛的治疗提供了新思路。Interleukin-33(IL-33),a new member of the IL-1 superfamily of cytokines,plays a regulatory role in various pain responses.A literature review on IL-33 levels in various diseases such as inflammatory pain,neuropathic pain,bone cancer pain,hand-arm vibration syndrome,bladder pain syndrome,and acute myocardial infarction revealed that IL-33 is differentially expressed in different tissues and systems and IL-33 can induce growth stimulation expressed gene 2 protein(ST2)receptor(especially in T-helper 2 cells and mast cells)expresses extensively,produce pro-inflammatory substances in an NF-κB-dependent manner,release signaling factors,activate the onset of inflammatory responses in downstream pathways,and then participate in T-cell-mediated immune responses,which provides a new idea for the treatment of pain.

关 键 词：白细胞介素-33 疼痛 促炎物质 免疫应答 

分 类 号：R-1[医药卫生] R338