脑出血后神经炎症的研究进展  

The research progress of neuroinflammation after intracerebral hemorrhage

作　　者：张瑛 周德生[2] Zhang Ying;Zhou De-sheng(Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]湖南中医药大学第一附属医院脑病一科,湖南长沙410021

出　　处：《中国急救医学》2022年第4期347-352,共6页Chinese Journal of Critical Care Medicine

基　　金：国家自然科学基金(81874463);湖南省科技厅科技创新平台与人才计划(2017SK4005);湖南省科技厅重点专项(2017SK2111);湖南省中医药管理局资助项目(201824);湖南省重点研发计划(2020SK2092);湖南省级财政中医药项目名院工程院内优势病种(rsk-010-13[006-09]);湖南省中医补助专项—中医质量控制中心(ywk-010-11)。

摘　　要：脑出血(intracerebral hemorrhage, ICH)是指原发性非外伤性脑实质内出血,是致死率极高的卒中亚型。目前针对ICH的治疗手段极其有限。神经炎症在ICH后早期继发性脑损伤和后期促进神经功能恢复的过程中占据重要地位。本综述将阐述有关ICH后具有双向调控神经炎症的小胶质细胞、淋巴细胞、凝血酶和基质金属蛋白酶-9和可能通过调控神经炎症来治疗ICH的药物或联合外科干预,且该药物已经被广泛用于治疗其他中枢神经系统疾病,有利于临床使用。Intracerebral hemorrhage(ICH) is primary non-traumatic intracerebral hemorrhage, which is a subtype of stroke with high mortality. The treatment of ICH to date is extremely limited. Neuroinflammation plays an important role in the process of early secondary brain injury and late neural function recovery after ICH. This review will describe the microglia, lymphocytes, thrombin and matrix metalloproteinase-9 which have bidirectional regulation of neuroinflammation after ICH, and surgery and the drugs that not only have been widely used in the treatment of other central nervous system, but also is highly possible to treat ICH by regulating neuroinflammation, which is convenient to clinical apply.

关 键 词：脑出血(ICH) 神经炎症 继发性脑损伤 小胶质细胞 

分 类 号：R743.34[医药卫生—神经病学与精神病学]