Adhesion-enhancing coating embedded with osteogenesis-promoting PDA/HA nanoparticles for peri-implant soft tissue sealing and osseointegration  

作　　者：Tingshu Su Ao Zheng Lingyan Cao Lingjie Peng Xiao Wang Jie Wang Xianzhen Xin Xinquan Jiang 

机构地区：[1]Department of Prosthodontics,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China [2]College of Stomatology,National Center for Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Jiao Tong University,Shanghai 200011,China [3]Shanghai Key Laboratory of Stomatology,Shanghai Engineering Research Center of Advanced Dental Technology and Materials,Shanghai 200011,China

出　　处：《Bio-Design and Manufacturing》2022年第2期233-248,共16页生物设计与制造（英文）

基　　金：funded by the National Natural Science Foundation of China(Nos.81801006,31870953,81901048,81620108006,81991505,81921002,81801023,and 82100963);Shanghai Rising-Star Program(21QA1405400);the National Key Research and Development Program of China(No.2016YFC1102900);Innovative Research Team of High-Level Local Universities in Shanghai(No.SSMU-ZDCX20180900)。

摘　　要：Following dental implantation,the characteristic bacterial milieu of the oral cavity may lead to peri-implant inflammation,which can negatively impact osseointegration and cause implant failure.To improve soft tissue sealing around the implant,enhance osseointegration,and improve implant success rates,this paper proposes a composite multifunctional coating(PHG)prepared using gelatin and polydopamine/hydroxyapatite nanoparticles,investigates the effects of this novel coating on cell adhesion,proliferation,antibacterial activity,osteogenic differentiation,and evaluates its immune-related properties.The PHG coating was proved to have satisfactory hydrophilicity and wettability for cell attachment.Furthermore,it improved the expression of adhesion-related genes and proteins in human gingival fibroblasts,indicating its adhesion-promoting effect.Additionally,bone marrow mesenchymal stem cells exhibited strong osteogenic differentiation potential and mineralization on PHG-coated surfaces.Notably,the PHG coating exhibited antibacterial activity against Streptococcus mutans,as well as anti-inflammatory effects,potentially via the regulation of macrophages.Therefore,the proposed PHG coating may promote soft tissue sealing and bone bonding,providing a potential strategy for the surface modification of dental implants.

关 键 词：Dental implantation Multifunctional coating Titanium OSSEOINTEGRATION Soft tissue sealing 

分 类 号：R783.1[医药卫生—口腔医学]