偏头痛药理实验模型研究进展  

Research progress of migraine pharmacology experimental model

作　　者：张泽鹏 郭颖[2] 李霖[1] 刘虹[3] 房士明[1,3] 张晗[1] ZHANG Zepeng;GUO Ying;LI Lin;LIU Hong;FANG Shiming;ZHANG Han(Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Department of Neurology,Tianjin Nankai Hospital,Tianjin 300100,China;Tianjin State Key Laboratory of Modern Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学,方剂学教育部重点实验室,天津301617 [2]天津市南开医院神经内科,天津300100 [3]天津中医药大学,天津现代中药重点实验室,天津301617

出　　处：《天津中医药大学学报》2022年第2期258-264,共7页Journal of Tianjin University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82004331);天津市高等学校创新团队项目(TD13-5053)。

摘　　要：偏头痛是困扰人类身心健康的疾病。近年来偏头痛的药理实验模型不断发展,有利地促进了偏头痛药物的研究与开发。根据中医证候特点建立的偏头痛模型为阐释中医药防治偏头痛的药效及机制奠定了基础。本文对常用的偏头痛模型进行归纳总结,包含实验模型的建立机制、造模方法、评价标准与特点,为后续中医药研究提供参考。Migraine has always been a disease that has plagued human physical and psychological healthy.With the continuous development of migraine pharmacological experimental models in recent years,it has favorably promoted the research and development of migraine drugs.The migraine models for different syndrome types established according to the characteristics of traditional Chinese medicine syndromes laid a foundation for explaining the efficacy and mechanism of traditional Chinese medicine in preventing and treating migraine.The following will summarize the migraine models including pathogenesis,modeling methods,evaluation criteria and value.The above provides reference for follow-up research of traditional Chinese medicine.

关 键 词：中医药 偏头痛 偏头痛实验模型 

分 类 号：R747.2[医药卫生—神经病学与精神病学]