醋酸甲地孕酮联合雷莫司琼在改善恶性肿瘤化疗患者厌食症状中的效果研究  

Effect of Megestrol Acetate Combined with Ramosetron in Improving Anorexia Symptoms in Patients with Malignant Tumor Chemotherapy

作　　者：廖博贤 唐凌威 LIAO Boxian;TANG Lingwei(Department of Oncology,Qingyuan District People's Hospital,Qingyuan,Guangdong Province,511515 China)

机构地区：[1]清远市清新区人民医院肿瘤科,广东清远511515

出　　处：《世界复合医学》2022年第2期166-169,共4页World Journal of Complex Medicine

摘　　要：目的探究对恶性肿瘤化疗患者应用醋酸甲地孕酮联合雷莫司琼治疗对其厌食症状的影响。方法选取2018年5月—2020年5月于该院进行化疗的恶性肿瘤患者120例并以数表法随机分为两组,每组60例。对照组常规治疗,研究组联合使用醋酸甲地孕酮和雷莫司琼治疗,分析两组患者在治疗效果、体质指数(BMI)和卡氏评分(KPS)以及不良反应方面的差异。结果两组患者治疗缓解率分别为53.33%和48.33%,两组差异无统计学意义(χ^(2)=0.296,P=0.584);治疗后,研究组患者BMI指标及KPS评分均显著高于对照组患者,差异有统计学意义(t=2.693、9.505,P<0.05);两组不良反应总发生率分别为11.67%和35.00%,研究组发生率明显低于对照组,差异有统计学意义(χ^(2)=9.131,P=0.003)。结论将醋酸甲地孕酮和雷莫司琼联合应用于恶性肿瘤化疗患者中,可在不影响患者治疗效果的同时减少厌食症状的发生,从而改善身体状态和生活质量。Objective To explore the effect of megestrol acetate combined with ramosetron on the anorexia symptoms in patients with malignant tumor undergoing chemotherapy.Methods A total of 120 patients with malignant tumors who received chemotherapy in the hospital from May 2018 to May 2020 were selected and randomly divided into two groups by the digital table method.There were 60 cases in each group.The control group was given routine treatment,and the study group was given a combination of megestrol acetate and ramosetron.The differences in treatment effects,body mass index(BMI)and carr's score(KPS)scores,and adverse reactions were analyzed between the two groups.Results The remission rates in the two groups were 53.33% and 48.33%,respectively,and there was no statistically significant difference between the two groups(χ^(2)=0.296,P=0.584).After treatment,the BMI index and KPS score of the study group were significantly higher than those of the control group,and the difference was statistically significant(t=2.693,9.505,P<0.05).The total incidence of adverse reactions in the two groups was 11.67% and 35.00%,respectively,and the incidence in the study group was significantly lower than that in the control group,and the difference was statistically significant(χ^(2)=9.131,P=0.003).Conclusion The combined application of megestrol acetate and ramosetron in patients with malignant tumor chemotherapy can reduce the occurrence of anorexia symptoms without affecting the treatment effect of patients,thereby improving the physical state and quality of life.

关 键 词：醋酸甲地孕酮 雷莫司琼 恶性肿瘤 化疗 厌食症状 

分 类 号：R730.5[医药卫生—肿瘤]