2010年至2020年安阳肿瘤医院1258例食管胃交界部腺癌患者死因分析  

Analysis the Death Causes of 1258 Patients with Esophagogastric Junction Adenocarcinoma in Anyang Cancer Hospital from 2010 to 2020

作　　者：魏梦霞 宋昕[1] 徐瑞华 李爱丽[2] 赵学科[1] 李贝[1] 范宗民[1] 罗宏 杨苗苗[1] 王献增 高社干[1,5] 周福有 鲍启德[7] 王立东[1] WEI Meng-xia;SONG Xin;XU Rui-hua;LI Ai-li;Zhao Xue-ke;LI Bei;FAN Zong-min;LUO Hong;Yang Miao-miao;WANG Xian-zeng;GAO She-gan;ZHOU Fu-you;BAO Qi-de;WANG Li-dong(State Key Laboratory of Esophageal Cancer Prevention&Treatment and Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital,Zhengzhou University,Zhengzhou,China,450052;Linzhou Cancer Hospital,Linzhou,China,456500;Guangshan People’s Hospital,Guangshan,China,465499;Linzhou People’s Hospital,Linzhou,China,456500;State Key Laboratory of Esophageal Cancer Prevention&Treatment,Henan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment,Henan Key Laboratory of Cancer Epigenetics,Cancer Hospital,The First Affiliated Hospital(College of Clinical Medicine)of Henan University of Science and Technology,Luoyang,China,471003;Henan Anyang Cancer Hospital,Anyang,China,456500;Anyang Regional Hospital of Puyang,Puyang,China,455000)

机构地区：[1]郑州大学第一附属医院省部共建食管癌防治国家重点实验室,河南郑州450052 [2]林州市肿瘤医院,河南林州456500 [3]光山县人民医院,河南光山465499 [4]林州市人民医院,河南林州456500 [5]河南科技大学临床医学院,河南科技大学第一附属医院,肿瘤医院,省部共建食管癌防治国家重点实验室,河南省微生态与食管癌防治重点实验室,河南省肿瘤表观遗传重点实验室,中国洛阳471003 [6]安阳肿瘤医院,河南安阳456500 [7]濮阳市安阳地区医院,河南濮阳455000

出　　处：《食管疾病》2022年第1期25-28,共4页Journal of Esophageal Diseases

基　　金：国家自然科学基金面上项目(81872032)。

摘　　要：目的分析食管胃交界部腺癌(AEG)患者死因情况,为AEG防治提供参考依据。方法回顾性分析省部共建食管癌防治国家重点实验室收集的、2010年至2020年河南省安阳肿瘤医院收治的、1258例AEG死亡患者的临床信息及随访资料,对患者以年龄(<40岁、40~60岁、≥60岁)、性别(男性/女性)、地区分布(城市/农村)分组进行死因分析。结果AEG患者从30岁开始,随着年龄不断增大,发病率越来越高,最高发年龄段为65~70岁,之后随着年龄不断升高,发病率迅速下降;AEG患者大多因本病(50.87%)去世,其次为食管癌(6.20%)、转移或扩散(4.37%)、心血管疾病(1.03%)、胃癌(1.3%)、胰腺癌(0.08%)、肝癌(0.08%)、膀胱癌(0.08%)、尿毒症(0.08%);40~60岁患者死亡前2位的死因分别是AEG(46.54%)和食管癌(6.29%);农村AEG死亡率占总患病人数的81.48%,远高于城市人口;男性相比于女性,AEG患病率更高。结论AEG对河南安阳居民健康危害程度较高,通过分析AEG患者死因情况,为AEG的防治工作提供参考依据。Objective To provide reference for the prevention and treatment of esophagogastric junction adenocarcinoma(AEG),by analyzing the death causes in patients with the disease.Methods The clinical information and follow-up data of 1258 patients who died in AEG in our hospital from 2010 to 2020 were analyzed retrospectively.Their age(<40 years old,40~60 years old,≥60 years old),gender,and regional distribution(urban/rural)were analyzed.Results The incidence of esophagogastric junction adenocarcinoma was increasing with age from 30 years old,the highest age was 65~70 years old,and then decreased rapidly with age.Most of the patients with esophagogastric junction adenocarcinoma died of this disease itself(50.87%),followed by esophageal cancer(6.20%),metastasis or spread(4.37%),cardiovascular disease(1.03%),gastric cancer(1.3%),pancreatic cancer(0.08%),liver cancer(0.08%),bladder cancer(0.08%),uremia(0.08%).The top two causes of death in 40~60 years old patients were esophagogastric junction adenocarcinoma(46.54%)and esophageal cancer(6.29%),respectively.The mortality of esophagogastric junction adenocarcinoma in rural areas accounted for 81.48%of the total number of patients,which was much higher than that of urban population.Esophagogastric junction adenocarcinoma is more common in men than in women.Conclusion AEG has a high risk to the health of residents in Anyang.This paper provides a reference for the prevention and treatment of esophagogastric junction adenocarcinoma.

关 键 词：食管胃交界部腺癌 死因 死亡率 年龄 性别 

分 类 号：R735.1[医药卫生—肿瘤]