122例罕见转移部位食管胃交界部腺癌的临床特点  

Clinical Features of 122 Cases of Esophagogastric Junction Adenocarcinoma with Rare Sites of Metastases

作　　者：雷玲玲 赵学科[1] 宋昕[1] 徐瑞华 魏梦霞 李贝[1] 范宗民[1] 胡景峰 杨苗苗[1] 罗宏 郭贵周 高社干[4] 周福有[5] 王立东[1] LEI Ling-ling;ZHAO Xue-ke;SONG Xin;XU Rui-hua;WEI Meng-xia;LI Bei;FANG Zong-min;HU Jing-feng;YANG Miao-miao;LUO Hong;GUO Gui-zhou;GAO She-gan;ZHOU Fu-you;WANG Li-dong(State Key Laboratory of Esophageal Cancer Prevention&Treatment and Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital,Zhengzhou University,Zhengzhou,China,450052;Guangshan County People’s Hospital,Guangshan,China,465450;Tumor Hospital of Linzhou,Linzhou,China,456500;State Key Laboratory of Esophageal Cancer Prevention&Treatment,Henan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment,Henan Key Laboratory of Cancer Epigenetics,Cancer Hospital,The First Affiliated Hospital(College of Clinical Medicine)of Henan University of Science and Technology,Luoyang,China,471003;Anyang Tumor Hospital,Anyang,China,455000)

机构地区：[1]郑州大学第一附属医院省部共建食管癌防治国家重点实验室,河南郑州500522 [2]光山县人民医院,河南光山465450 [3]林州市肿瘤医院,河南林州456500 [4]河南科技大学临床医学院,河南科技大学第一附属医院,肿瘤医院,省部共建食管癌防治国家重点实验室,河南省微生态与食管癌防治重点实验室,河南省肿瘤表观遗传重点实验室,中国洛阳471003 [5]安阳市肿瘤医院,河南安阳455000

出　　处：《食管疾病》2022年第1期29-31,共3页Journal of Esophageal Diseases

基　　金：国家自然科学基金项目(U1804262,81872032)。

摘　　要：目的分析罕见转移部位食管胃交界部腺癌(AEG)的临床特点。方法回顾性分析122例罕见转移部位AEG患者的临床诊疗资料,数据均来自省部共建食管癌防治国家重点实验室50万例食管癌和贲门癌临床信息数据库。罕见转移部位定义为除淋巴结、肝、肺、食管、胃转移之外的转移部位。结果在122例罕见转移部位的AEG患者中,相对常见转移部位依次为腹腔(18.03%,22/122),骨(16.39%,20/122),脑(12.30%,15/122),肠(9.02%,11/122),腹壁(9.02%,11/122),乳腺(5.74%,7/122),胰腺(4.92%,6/122),子宫(4.10%,5/122),胆囊(2.46%,3/122),盆腔(2.46%,3/122),膀胱、腹股沟、卵巢、肾脏、输尿管、胸腔、纵膈(均为1.64%,2/122),脾脏、气管、肾上腺、声带、心脏(均为0.82%,1/122)。肿瘤家族史阳性的AEG罕见转移部位患者预后较阴性好。结论AEG转移部位广泛,除了常见转移部位外,还可转移至其他少见、罕见部位,临床医师在对AEG患者复查时应全面考虑可能转移的器官。肿瘤家族史阳性可能是AEG罕见转移部位患者预后的保护因素。Objective To analyze the clinical features of adenocarcinoma of the esophagogastric junction(AEG)at the rare metastasis sites.Methods The clinical diagnosis and treatment data of 122 AEG patients with the rare metastasis sites were retrospectively analyzed,and the data were from the 500000 cases of esophageal cancer and cardiac cancer clinical information database of the State Key Laboratory of Esophageal Cancer Prevention and Control jointly established by the province and the ministry.Rare metastases are defined as rare metastases other than lymph nodes,liver,lungs,esophagus,and stomach metastases.Results In 122 AEG patients with rare metastases,the relatively common metastases were abdominal cavity(18.03%,22/122),bone(16.39%,20/122),brain(12.30%,15/122),intestine(9.02%,11/122),abdominal wall(9.02%,11/122),breast(5.74%,7/122),pancreas(4.92%,6/122),uterus(4.10%,5/122),gallbladder(2.46%,3/122),pelvic cavity(2.46%,3/122),bladder,groin,ovaries,kidneys,ureter,chest cavity,mediastinum(all:1.64%,2/122),spleen,trachea,adrenal glands,vocal cords,heart(all:0.82%,1/122).Patients with a positive family history of AEG at rare metastases have a better prognosis than the negative.Conclusion In addition to the common metastatic sites,it can also metastasize to other rare sites,and clinicians should fully consider the organs that may be metastasized when reviewing AEG patients.A positive family history of cancer may be a protective factor in prognosis for patients with rare metastases in AEG.

关 键 词：食管胃交界部腺癌 罕见转移部位 临床特点 

分 类 号：R735.1[医药卫生—肿瘤]