CPP-ACP联合氟化物用于釉质再矿化研究进展  

Research progress in CPP-ACP combined with fluoride on enamel remineralization

作　　者：徐煜 邹慧儒 Xu Yu;Zou Huiru(Central Laboratory of Tianjin Stomatological Hospital,School of Medicine,Nankai University,Tianjin 300041,China;Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction,Tianjin 300041,China;State Key Laboratory of Medicinal Chemical Biology(Nankai University),Tianjin 300071,China)

机构地区：[1]天津市口腔医院中心实验室,南开大学医学院300041 [2]天津市口腔功能重建重点实验室,300041 [3]药物化学生物学国家重点实验室(南开大学),天津300071

出　　处：《国际生物医学工程杂志》2021年第5期388-394,共7页International Journal of Biomedical Engineering

基　　金：天津市自然科学基金(18JCYBJC27000);天津市卫生健康委重点项目(ZD20016);药物化学生物学国家重点实验室(南开大学)开放基金资助课题(2018012);全牙再生与口腔组织功能重建北京市重点实验室开放课题项目(KFKT2017008)。

摘　　要：随着人民生活水平的提高以及龋病防治意识的加强,釉质再矿化受到了广泛关注。目前研究较多的再矿化剂有氟化物、生物活性玻璃和酪蛋白磷酸肽-无定形磷酸钙(CPP-ACP)等,均具有一定的促进釉质再矿化作用。CPP-ACP与氟化物联合应用更是成为当前的研究热点之一。然而,不同研究的结果显示CPP-ACP联合氟化物的作用效果存在较大差异,其可能受多种因素影响。就近年来CPP-ACP与氟化物联合应用促进釉质再矿化的研究进展进行综述,重点分析各影响因素,以期为未来实验设计及临床应用提供参考。With the improvement of people's living standard and the strengthening of people's recognition of dental caries prevention and treatment,enamel remineralization has attracted extensive attention.Fluoride,bioactive glass and casein phosphopeptide-amorphic calcium phosphate(CPP-ACP)are the most widely studied remineralisation agents at present,which have a certain effect of promoting enamel remineralization.The results of different studies shown that the effect of CPP-ACP combined with fluoride was quite different,which may be affected by many factors.In this paper,the recent progress of the combined application of CPP-ACP and fluoride on enamel remineralization was reviewed,and various influencing factors were analyzed in order to provide references for future experimental design and clinical applications.

关 键 词：牙釉质 牙再矿化 氟化物 酪蛋白磷酸肽-无定形磷酸钙 影响因素 

分 类 号：R781.1[医药卫生—口腔医学]