Hepatitis B virus-associated follicular lymphoma presents T-cell inflamed phenotype and response to lenalidomide  

作　　者：Nan Wang Wei Qin Zhong Zheng Ming Zhao Jie Xiong Hai Fang Rui Sun Yichao Wang Chen Li Lei DongXiaojian Sun Li Wang Pengpeng Xu Shu Cheng Haimin Xu Fan Zhang Weili Zhao 

机构地区：[1]State Key Laboratory of Medical Genomics,National Research Center for Translational Medicine at Shanghai,Shanghai Institute of HematologyRuijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,P.R.China [2]Network&Information Center,Shanghai Jiao Tong University,Shanghai 200025,P.R.China [3]Department of Pathology,Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,P.R.China [4]Laboratory of Molecular Pathology,Pôle de Recherches Sino-Français en Science du Vivant et Génomique,Shanghai 200025,P.R.China

出　　处：《Cancer Communications》2022年第2期170-174,共5页癌症通讯（英文）

基　　金：by research fund-ing from the National Natural Science Foundation of China(81830007 and 81900193);Chang Jiang Scholars Program,Shanghai Municipal Education Commission Gaofeng Clinical Medicine(20152206 and 20152208);Shanghai Sailing Program(19YF1430900),Clinical Research Plan of Shanghai Hospital Development Center(SHDC2020CR1032B);and Multicenter Clinical Research Project by Shanghai Jiao Tong University School of Medicine(DLY201601).

摘　　要：Dear Editor,Follicular lymphoma(FL)represents the most common subtype of indolent non-Hodgkin's lymphoma(NHL)with distinct pathological,cytogenetic,and molecular features,accounting for 9.7%of NHLs in China[1].FL maintains a differentiation stage similar to germinal center(GC)B cells and is divided into grades 1,2,3A,and 3B[2].Up to 90%of FLs harbor the t(14;18)(q32;q21)/BCL2 apoptosis regula-tor(BCL2)-immunoglobulin heavy locus(IGH)transloca-tion and epigenetic modifier mutations,particularly lysine methyltransferase 2D(KMT2D)and CREB-binding pro-tein(CREBBP)[2].

关 键 词：lymphoma BCL2 NHL 

分 类 号：R73[医药卫生—肿瘤]