Molecular Mechanisms Underlying Cell-Fate Specification and Cellular Diversity of the Trophoblast Lineage during Placental Morphogenesis in Mice  

作　　者：Jian-Qi Wang Change Mu Yang Sun Jin-Hua Lu Hai-Bin Wang 

机构地区：[1]Department of Obstetrics and Gynecology,The First Affiliated Hospital of Xiamen University,School of Medicine,Xiamen University,Xiamen,Fujian 361003,China [2]Fujian Provincial Key Laboratory of Reproductive Health Research,School of Medicine,Xiamen University,Xiamen,Fujian 361102,China

出　　处：《Reproductive and Developmental Medicine》2021年第4期220-236,共17页生殖与发育医学（英文版）

基　　金：National Key R&D Program of China(2018YFC1004102 to J.L.);National Natural Science Foundation of China(81830045 to H.W., 31971071 and 82171660 to J.L., and 31701016 to J. W.)

摘　　要：Placental morphogenesis is a highly dynamic process involving mutual recognition and interlacing between the trophoblast-uterus and ultimately the initiation of the maternal-fetal circulatory system.During placental morphogenesis in mice,the trophoblast lineage,which integrates maternal and fetal signaling,undergoes stage-specific changes in gene regulatory programs directing cellular proliferation and fate specification,generating diverse trophoblast subtypes.While accumulating evidence from studies on genetically engineered and mutant mice has revealed the involvement of cell-specific core transcription factors in certain key events during placental morphogenesis,the precise molecular mechanisms by which multipotent trophoblasts gradually differentiate into different subtypes are still largely unknown.In this review,we primarily focus on mutant mouse models with placental phenotypes to provide a comprehensive understanding of the molecular mechanisms underlying cell-fate specification and cellular diversity of the trophoblast lineage during the placental morphogenesis.

关 键 词：Differentiation MORPHOGENESIS MULTIPOTENCY PLACENTA TROPHOBLAST 

分 类 号：R714.1[医药卫生—妇产科学]