LncRNA调控肿瘤细胞辐射敏感性作用的研究进展  

Research progress in the role of lncRNA in regulating radiationsensitivity of cancer cells

作　　者：赵舒雅 李航 樊赛军[1] Zhao Shuya;Li Hang;Fan Saijun(Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,Institute of Radiation Medicine,Chinese Academy of Medical Sciences,Peking Union Medical College,Tianjin 300192,China)

机构地区：[1]中国医学科学院北京协和医学院放射医学研究所,天津市放射医学与分子核医学重点实验室,300192

出　　处：《国际放射医学核医学杂志》2021年第11期701-709,共9页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金(81803046、81730086);中国医学科学院医学与健康科技创新工程(2021-I2M-1-042)。

摘　　要：放疗是治疗恶性肿瘤的主要方法之一,但放疗的效果在不同类型的肿瘤及个体间都存在差异,解决这一问题的重要手段之一是提高肿瘤的放射敏感性。长链非编码RNA(lncRNA)通过多种机制影响肿瘤细胞的放射敏感性,未来有望成为放疗的辅助治疗靶点。笔者综述了lncRNA参与肿瘤放疗抵抗过程的作用模式及其相关的分子机制。Radiotherapy is one of the main modalities of cancer treatment,but the benefits from radiotherapy varies among different types of tumors and individuals.One of the important means to solve this problem is to improve the radiosensitivity of tumor tissues.Recent studies have shown that long non-coding RNA(lncRNA)influences the radiosensitivity of tumor cells through multiple mechanisms,and is expected to be an adjuvant therapeutic target for radiotherapy in the near future.In this paper,the authors review the action of lncRNA involved in the process of tumor radiotherapy resistance and its related molecular mechanisms.

关 键 词：辐射耐受性 放射疗法 RNA 长链非编码 

分 类 号：R730.55[医药卫生—肿瘤]