T细胞性淋巴母细胞淋巴瘤预后分析  

The prognostic analysis of T-cell lymphoblastic lymphoma

作　　者：倪丽红 何芳 何玮 胡慧仙 Ni Lihong

机构地区：[1]浙江大学医学院附属金华医院,321000

出　　处：《浙江临床医学》2022年第3期326-328,共3页Zhejiang Clinical Medical Journal

基　　金：金华市科技计划项目(2018-3-006)。

摘　　要：目的探讨T细胞性淋巴母细胞淋巴瘤(T-LBL)的临床特征和预后影响因素。方法回顾性分析2015年1月至2019年6月20例T-LBL患者的临床资料。患者均接受CHOP样或ALL样化疗,其中10例衔接干细胞移植。结果20例患者中位发病年龄17岁,男女比例为2.3:1。全组患者评估疗效,获得完全缓解(CR)8例,部分缓解(PR)2例,其中衔接移植6例获得CR。单纯化疗和移植两组2年预估总体生存期(OS)分别为13.9%、53.3%。Ki-67≥50%、高LDH水平、疾病累及中枢神经系统及仅接受单纯化疗是T-LBL患者的不良预后因素(P<0.05)。结论T-LBL是一类侵袭度高、预后差的血液系统恶性肿瘤,经过诱导化疗后衔接造血干细胞移植可改善预后。Objective To investigate the clinical characteristics and prognostic factors of patients with T-cell lymphoblastic lymphoma(T-LBL).Methods The clinical data of 20 T-LBL patients from January 2015 to June 2019 were retrospectively analyzed.All patients received CHOP-like or ALL-like chemotherapy,and 10 of them underwent stem cell transplantation.Results The median age of onset was 17 years old for the 20 patients,and the male-to-female ratio was 2.3:1.The efficacy of the whole patients was evaluated,and 8 cases achieved complete remission(CR)and 2 cases of partial remission(PR).6 cases of bridging transplantation achieved CR.The 2-year estimated OS for chemotherapy alone and transplantation were 13.9%and 53.3%,respectively.Ki-67≥50%,high LDH levels,disease involving the central nervous system,and chemotherapy alone were associated with poor prognosis.Conclusion T-LBL is a type of hematological malignancy with high invasiveness and poor prognosis.After induction chemotherapy,hematopoietic stem cell transplantation can improve the prognosis.

关 键 词：T细胞性淋巴母细胞淋巴瘤 临床特点 造血干细胞移植 

分 类 号：R73[医药卫生—肿瘤]