Laser speckle contrast imaging for monitoring of acutepancreatitis at ischemia-reperfusion injury of thepancreas in rats  

作　　者：P.A.Dyachenko(Timoshina) A.N.Bashkatov D.A.Alexandrov V.I.Kochubey V.V.Tuchin 

机构地区：[1]Saratov State University,Saratov,Russia [2]Laboratories of Biophotonics and Laser Molecular Imaging and Machine Learning National Research Tomsk State University,Tomsk,Russia [3]Saratov State Medical University,Saratov,Russia [4]Institute of Precision Mechanics and Control,Russian Academy of Sciences,Russia [5]A.N.Bach Institute of Biochemistry,Research Center of Biotechnology of the Russian Academy of Sciences Moscow,Russia

出　　处：《Journal of Innovative Optical Health Sciences》2022年第1期90-102,共13页创新光学健康科学杂志（英文）

基　　金：the nancial sup-port of the Project No.13.2251.21.0009 of the Ministry of Science and Higher Education of the Russian Federation.

摘　　要：The influence of ischemia-reperfusion(I/R)action on pancreatic blood flow(PBF)and the development of acute pancreatitis(AP)in laboratory rats is evaluated in vivo by using the laser speckle contrast imaging(LSCI).Additionally,the optical properties in norm and under condition of AP in rats were assessed using a modied integrating sphere spectrometer and inverse Monte Carlo(IMC)software.The results of the experimental study of microcirculation of the pancreas in 82 rats in the ischemic model are presented.The data obtained conrm the fact that local ischemia and changes in the blood°ow velocity of the main vessels cause and provoke acute pancreatitis.

关 键 词：Laser speckles contrast of speckle images adaptive algorithm MICROCIRCULATION blood flow acute pancreatitis PANCREAS RATS optical properties integrating sphere spectroscopy 

分 类 号：R576[医药卫生—消化系统]