雄激素与干眼  

Correlation between androgen and dry eye

作　　者：张鹏 接英 Zhang Peng;Jie Ying(Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Key Laboratory of Ophthalmology and Visual Sciences,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院,北京同仁眼科中心,北京市眼科研究所,眼科学与视觉科学北京市重点实验室,100730

出　　处：《国际眼科纵览》2022年第1期51-54,共4页International Review of Ophthalmology

摘　　要：干眼是一种多因素导致的眼表疾病。女性的患病率高于男性,尤其是绝经后女性。这种性别差异很大程度上与性激素有关。目前雌激素在眼表的作用仍有争议,但雄激素对眼表的保护作用已经明确。眼表雄激素主要来源于雄激素前体在局部组织内的合成,通过结合眼表组织内的雄激素受体发挥作用。动物实验及临床研究均证实雄激素缺乏会导致泪腺损伤和MGD,雄激素替代疗法对水液缺乏型干眼和蒸发过强型干眼具有潜在的治疗作用。Dry eye is a multifactorial disease of the ocular surface,which occurs more frequently in women than men,especially postmenopausal women.This sex-related difference in dry eye prevalence is attributed in large part to the effects of sex steroids.At present,the role of estrogen at the ocular surface is less well defined,but the protective effect of androgen at the ocular surface have been clear.Androgen on the ocular surface is mainly derived from the synthesis of androgen precursor in local tissues.Androgen functions by combining with androgen receptors on the ocular surface.Animal experiments and clinical studies have confirmed that androgen deficiency can cause destruction of the lacrimal gland,leading to aqueous deficient dry eye,or meibomian gland dysfunction,reducing the lipid component of the tear film,leading to evaporative dry eye and androgen replacement therapy can be considered to treat aqueous-deficient dry eye and evaporative dry eye.

关 键 词：雄激素 干眼 睑板腺功能障碍 雄激素替代治疗 

分 类 号：R777.34[医药卫生—眼科]