NF-κB相关信号通路在胃炎-癌疾病链中的作用机制  

Mechanism of action of NF-κB related cell signaling pathways in progression of gastritis to carcinoma

作　　者：谢咚 孙明瑜[1] Dong Xie;Ming-Yu Sun;Shuguang(Hospital,Key Laboratory of Liver and Kidney Diseases(Ministry of Education),Institute of Liver Diseases,Shanghai University of Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院,上海中医药大学肝病研究所肝肾疾病病证教育部重点实验室,上海中医药大学,上海市201203

出　　处：《世界华人消化杂志》2022年第6期255-259,共5页World Chinese Journal of Digestology

基　　金：国家中医药管理局第四批中医优才项目,No.2017-124;上海市科技创新行动计划,No.19401972300;山东省2021年重点研发计划(重大科技创新工程),No.2021CXGC010509;国家中医药管理局中医肝胆病重点学科、慢性肝病虚损重点研究室和上海市中医临床重点实验室,No.20DZ2272200.

摘　　要：胃癌(gastric cancer,GC)作为全球重大的公共卫生问题,浅表性胃炎-慢性萎缩性胃炎-肠上皮化生-异型增生-胃癌”的发病模式在胃疾病中常见.作为参与机体应激、炎症反应及细胞凋亡等过程中的关键因子,NF-κB相关的炎症反应和细胞凋亡调控是炎-癌进展疾病链的必要环节,在大多数实体肿瘤和淋巴瘤中,NF-κB均有激活.在各种病因诱发的胃炎致胃癌的关键节点机制中,细胞长期在炎症反应的微环境中,NF-κB信号通路上下游分子发生改变,最终导致其促癌潜能的发挥.本篇论述了NF-κB在胃炎癌转变进展中的关键机制.Gastric cancer(GC)is a major global public health problem.The evolvement pattern of“superficial gastritis-chronic atrophic gastritis-intestinal metaplasia-dysplasia-gastric carcinoma”is common in related gastric diseases.As a key factor involved in systemic stress response,inflammatory response,and apoptosis,the regulation of NF-κB related to inflammation and apoptosis is a necessary link between inflammation and cancer progression.NF-κB is activated in most solid tumors and lymphomas.In the critical mechanism of gastric cancer induced by gastritis with various etiologies,the upstream and downstream molecules in the NF-κB signaling pathway are changed,and the cells are exposed to the microenvironment of inflammatory response for a long time,which ultimately leads to the development of their carcinogenic potential.This article discusses the mechanism of NF-κB in the key risk factors for the progression of gastric disease.

关 键 词：NF-ΚB 慢性胃炎 胃不典型增生 胃癌 信号通路 

分 类 号：R735.2[医药卫生—肿瘤]