Pediatric liver transplantation outcomes from a single center in Thailand  

作　　者：Sittichoke Prachuapthunyachart Palittiya Sintusek Chomchanat Tubjareon Nataruks Chaijitraruch Anapat Sanpavat Teerasak Phewplung Piyaporn Wanawongsawad Ai-lada Intrarakamhang Voranush Chongsrisawat 

机构地区：[1]Department of Pediatrics,Faculty of Medicine,Chulalongkorn University and King Chulalongkorn Memorial Hospital,Bangkok 10330,Thailand [2]Thai Pediatric Gastroenterology,Hepatology and Immunology Research Unit,Department of Pediatrics,Faculty of Medicine,King Chulalongkorn Memorial Hospital,Thai Red Cross,Chulalongkorn University,Bangkok 10330,Thailand [3]Excellence Center of Organ Transplantation,King Chulalongkorn Memorial Hospital,Bangkok 10330,Thailand [4]Department of Pathology,Faculty of Medicine,Chulalongkorn University and King Chulalongkorn Memorial Hospital,Bangkok 10330,Thailand [5]Department of Radiology,Faculty of Medicine,Chulalongkorn University and King Chulalongkorn Memorial Hospital,Bangkok 10330,Thailand

出　　处：《World Journal of Hepatology》2022年第3期583-591,共9页世界肝病学杂志（英文版）（电子版）

摘　　要：BACKGROUND Liver transplantation(LT)has become an acceptable curative method for children with several liver diseases,especially irreversible acute liver failure and chronic liver diseases.King Chulalongkorn Memorial Hospital is one of Thailand’s largest liver transplant centers and is responsible for many pediatric cases.AIM To report the experience with pediatric LT and evaluate outcomes of livingrelated vs deceased-donor grafts.METHODS This evaluation included children who underwent LT between August 2004 and November 2019.Data were retrospectively reviewed,including demographics,diagnoses,laboratory values of donors and recipients,the pediatric end-stage liver disease(PELD)or model for end-stage liver disease(MELD)score,graft source,wait time,perioperative course,postoperative complications,and survival rates.Continuous data were reported using the median and interquartile range.The Mann–Whitney U-test was used to compare the wait time between the living-related and deceased-donor groups.The chi-square or Fisher's exact test were used to compare the frequencies of between-group complications.Survival rates were calculated using the Kaplan–Meier method.RESULTS Ninety-four operated pediatric liver transplant patients were identified(54%were females).The median age at transplantation was 1.2(0.8-3.8)years.The median PELD and MELD scores were 20(13-26.8)and 19.5(15.8-26.3),respectively.Most grafts(81.9%)were obtained from living-related donors.The median wait time for the living donors was significantly shorter compared with the deceased donors at 1.6(0.3-3.1)mo vs 11.2(2.1-33.3)mo(P=0.01).Most patients were diagnosed with biliary atresia(74.5%),and infection was the most common complication within 30 d posttransplantation(14.9%).Without a desensitization protocol,9%of transplants were ABOincompatible.Eight hepatitis B core antibodies(anti-HBc)-negative recipients received positive anti-HBc grafts without different observed complications.The overall survival rate was 93.6%and 90.3%at 1 and 5 years,respectiv

关 键 词：PEDIATRIC Liver transplantation Living-donor Hepatitis B ABO-INCOMPATIBLE SURVIVAL 

分 类 号：R726.5[医药卫生—儿科]