帕金森病患者ApoA-1水平与UPDRS评分、MMSE评分及脑白质微结构改变的关系  

The relationship between ApoA-1 level and UPDRS score,MMSE score and cerebral white matter microstructure changes in patients with Parkinson’s disease

作　　者：史靖 胡军[1] 罗开亮 贾绍环 沈鹤 胡泽凯 刘欣昊 刘婷[1] SHI Jing;HU Jun;LUO Kailiang;JIA Shaohuan;SHEN He;HU Zekai;LIU Xinhao;LIU Ting(Department of Rehabilitation,Shanghai University of Traditional Chinese Medicine,Shanghai,China,201203;Department of Rehabilitation,Baoshan Branch,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,China,201203)

机构地区：[1]上海中医药大学,上海201203 [2]上海交通大学医学院附属仁济医院宝山分院康复科,上海201203

出　　处：《分子诊断与治疗杂志》2022年第3期422-425,共4页Journal of Molecular Diagnostics and Therapy

基　　金：上海市宝山区科学技术委员会科技创新专项资金项目(20-E-36)。

摘　　要：目的探究帕金森病(PD)患者ApoA-1水平与UPDRS评分、MMSE评分及脑白质微结构改变的关系。方法分析上海交通大学医院附属仁济医院宝山分院康复科2020年6月至2021年10月收治的83例PD患者的临床资料,另选取同期来本院行健康体检的40例患者作为对照组。对比两组ApoA-1水平,采用UPDRS评分评价两组患者精神行为、情绪、日常活动及运动功能,采用MMSE评分评价两组患者认知障碍水平,利用磁共振弥散张量成像检查两组患者脑白质微结构变化情况,使用Person相关性分析ApoA-1水平与UPDRS评分、MMSE评分及脑白质区域部分FA值的关系。结果PD患者ApoA-1水平、MMSE量表评分较对照组低,UPDRS量表评分较对照组高,差异均有统计学意义(P<0.05);PD患者脑白质不同区域FA值均较对照组低,差异有统计学意义(P<0.05);PD患者ApoA-1水平与UPDRS、MMSE量表评分、脑白质不同区域FA值相关(P<0.05)。结论PD表现为ApoA-1水平下降,该水平与患者认知功能及脑白质微结构改变密切相关,临床检测ApoA-1水平对于判断患者是否存在认知障碍具有显著意义。Objective To explore the relationship between ApoA-1 level and UPDRS score,MMSE score,and white matter microstructure changes in Parkinson’s disease(PD)patients.Methods A retrospective analysis of the clinical data of 83 PD patients admitted to the Rehabilitation Department of Renji Hospital Baoshan Branch of Shanghai Jiaotong University Hospital from June 2020 to October 2021,and 40patients who came to our hospital for physical examination during the same period were selected as the control group.The levels of ApoA-1 in the two groups were compared,the UPDRS score was used to evaluate the mental behavior,mood,daily activities or motor function of the two groups of patients.Magnetic resonance diffusion tensor imaging was used to examine the changes of white matter microstructure in the two groups of patients,and Person correlation was used to analyze the relationship between ApoA-1 level and UPDRS score,MMSE score and partial FA value in white matter area.Results The ApoA-1 level and MMSE scale score in the PD patients were lower than those in the control group,and the UPDRS scale score was higher than that in the control group,and the differences were statistically significant(P<0.05).the FA values of different areas of the white matter in the PD patients were lower than those in the control group(P<0.05)The level of Apo A-1in PD patients was correlated with UPDRS,MMSE scale scores,and FA values in different regions of white matter(P<0.05).Conclusion PD is manifested as a decrease in the level of Apo A-1,which is closely related to the changes in the patient’s cognitive function and white matter microstructure.Clinical detection of Apo A-1 level is of great significance for judging whether the patient has cognitive impairment.

关 键 词：帕金森病 载脂蛋白A-1 统一帕金森氏病评分量表 简易精神状态检查量表 脑白质微结构 

分 类 号：R742.5[医药卫生—神经病学与精神病学]