脑胶质瘤ABCC3、PEBP4及Anxa7的表达及与病理特征和预后的关系  

Expression of ABCC3,PEBP4 and Anxa7 in glioma and their relationship with pathological features and prognosis

作　　者：赵树鹏[1] 马继伟[1] 王向阳 胡朝帅 梁甲宁 葛立可 赵新利[1] ZHAO Shupeng;MA Jiwei;WANG Xiangyang;HU Chaoshuai;LIANG Jianing;GE Like;ZHAO Xinli(Department of Neurosurgery,the First Affiliated Hospital of Xinxiang Medical College,Xinxiang,Henan,China,453000)

机构地区：[1]新乡医学院第一附属医院神经外科,河南新乡453000

出　　处：《分子诊断与治疗杂志》2022年第3期434-438,共5页Journal of Molecular Diagnostics and Therapy

基　　金：河南省医学科技攻关计划项目(LHGJ20200503)。

摘　　要：目的 研究脑胶质瘤ATP结合盒转运蛋白3(ABCC3)、磷脂酰乙醇胺结合蛋白4(PEBP4)及膜联蛋白7(Anxa7)的表达与病理特征、预后的关系。方法 收集2016年5月至2018年6月于新乡医学院第一附属医院行肿瘤切除术的88例脑胶质瘤患者的胶质瘤组织作为实验组,同时收集瘤旁组织(距离肿瘤5 cm处)作为对照组;根据预后分为生存组(n=51)及死亡组(n=37)。对比各组间ABCC3、PEBP4及Anxa7表达情况;分析脑胶质瘤中ABCC3、PEBP4及Anxa7的表达与病理特征、预后的关系。结果 实验组ABCC3、PEBP4阳性率及Anxa7阴性率较对照组高,差异有统计学意义(P<0.05)。ABCC3、PEBP4阳性及Anxa7阴性患者的分化程度、远处转移、TNM分期高于ABCC3、PEBP4阴性及Anxa7阳性患者,差异具有统计学意义(P<0.05)。死亡组ABCC3、PEBP4阳性率及Anxa7阴性率较生存组高,差异有统计学意义(P<0.05)。组织分化程度、远处转移、TNM分期、ABCC3、PEBP4、Anxa7为影响脑胶质瘤预后的独立危险因素(P<0.05)。结论 脑胶质瘤中ABCC3、PEBP4阳性表达高,Anxa7阴性表达高,三者可作为脑胶质瘤患者病情预后有效评估指标。Objective To study the relationship between the expression of ATP binding cassette subfamily C member-3(ABCC3),phosphatidylethanolamine-binding protein-4(PEBP4),Annexin-7(Anxa7)and pathological characteristics and prognosis in brain gliomas. Methods The glioma tissues of 88 patients with glioma who underwent tumor resection in the First Affiliated Hospital of Xinxiang Medical College from May2016 to June 2018 were collected as the experimental group,and normal tissues adjacent to the tumor were collected as the control group;according to the prognosis they were divided into the survival group(n=51)and the death group(n=37). The expression of ABCC3,PEBP4 and Anxa7 among the groups was compared. The relationship between the expression of ABCC3,PEBP4 and Anxa7 in glioma tissue and pathological characteristics and prognosis in brain gliomas was analyzed. Results The positive rate of ABCC3,PEBP4 and the negative rate of Anxa7 in the experimental group were higher than those in the control group,and the difference was statistically significant(P<0.05). The degree of differentiation,distant metastasis,TNM stage of ABCC3,PEBP4 positive and Anxa7 negative patients was higher than those of ABCC3,PEBP4 negative and Anxa7 positive patients,and the difference was statistically significant(P<0.05). The positive rate of ABCC3,PEBP4 and the negative rate of Anxa7 in the death group were higher than those in the survival group,and the difference was statistically significant(P<0.05). The degree of tissue differentiation,distant metastasis,TNM staging,ABCC3,PEBP4,Anxa7 were independent risk factors affecting the prognosis of glioma(P<0.05).Conclusion The positive expression rate of ABCC3 and PEBP4 in glioma tissue is high,and the negative expression of Anxa7 is high. The three can be used as effective indicators for the prognosis of patients with glioma.

关 键 词：脑胶质瘤 ABCC3 PEBP4 Anxa7 

分 类 号：R739.41[医药卫生—肿瘤]