CD25、CRP及TLRs在小儿支气管哮喘合并感染中的预测作用  

Predictive role of CD25,CRP and TLRs in children with bronchial asthma complicated by infection

作　　者：朱琼琼 徐玄玄[1] 韦贞汁 赵喜燕[1] 周秦 ZHU Qiongqiong;XU Xuanxuan;WEI Zhenzhi;ZHAO Xiyan;ZHOU Qin(Department of Children's Emergency,Sanmenxia Central Hospital,Sanmenxia,Henan,China,472000;Department of Children's Emergency,the First Affiliated Hospital of Zhengzhou Medical University,Zhengzhou,Henan,China,450052)

机构地区：[1]三门峡市中心医院儿童急诊科,河南三门峡472000 [2]郑州医科大学第一附属医院儿童急诊科,河南郑州450052

出　　处：《分子诊断与治疗杂志》2022年第3期487-490,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省科技攻关计划项目(2019030358)。

摘　　要：目的分析外周血CD25、CRP及TLRs在小儿支气管哮喘中的表达及对合并感染的预测价值。方法选取2019年1月至2020年5月三门峡市中心医院接收的90例支气管哮喘患儿,根据是否合并感染分为合并组(n=32)和未合并组(n=58),同时选取64例同期行健康体检的正常儿童作为对照组。比较不同儿童CD25、CRP及TLRs水平,分析影响小儿支气管哮喘合并感染的危险因素及CD25、CRP及TLRs检测对小儿支气管哮喘合并感染的预测价值。结果研究组患儿CD25、CRP及TLRs水平高于对照组,差异有统计学意义(P<0.05)。合并组患儿外周血CD25、CRP及TLRs水平较未合并组高,差异有统计学意义(P<0.05)。白细胞值≥3.0×10^(9)/L、CD25、CRP、TLR2、TLR4异常升高为影响小儿支气管哮喘合并感染的独立危险因素(P<0.05)。CD25、CRP、TLR2、TLR4水平及四者联合检测诊断小儿支气管哮喘合并感染曲线下面积分别为0.918、0.949、0.878、0.905、1.000,各指标曲线下面积以联合检测最大(P<0.05)。结论支气管哮喘合并感染患儿CD25、CRP及TLRs水平呈高表达,联合上述指标检测对小儿支气管哮喘合并感染的诊断、病情评估具有重要价值。Objective To analyze the expression of peripheral blood CD25,CRP and TLRs in children with bronchial asthma and their predictive value for co-infection.Methods 90 children with bronchial asthma admitted to Sanmenxia Central Hospital from January 2019 to May 2020 were selected,and according to whether they had co-infections,they were divided into the combined group(n=32)and the non-combined group(n=58).At the same time,64 children who had physical examination during the same period were selected as the control group.The levels of CD25,CRP,and TLRs in different children were compared,and the risk factors affecting bronchial asthma in children and the predictive value of detection of CD25,CRP and TLRs in children with bronchial asthma were analyzed.Results The levels of CD25,CRP and TLRs in the study group were higher than those in the control group,and the difference was statistically significant(P<0.05).The levels of CD25,CRP and TLRs in the peripheral blood of the children in the combined group were higher than those in the uncombined group,and the difference was statistically significant(P<0.05).White blood cell value≥3.0×10^(9)/L,abnormal increasing of CD25,CRP,TLR4,and TLR3 were independent risk factors affecting coinfection in children with bronchial asthma(P<0.05).The area under the curve of CD25,CRP,TLR2,TLR4and the combined detection of the four in the diagnosis of pediatric bronchial asthma with infection were 0.918,0.949,0.878,0.905,and 1.000,respectively.The area under the combined test curve was the largest(P<0.05).Conclusion The levels of CD25,CRP and TLRs are highly expressed in children with bronchial asthma complicated by infection.Combined detection of the above indicators is of great value for the diagnosis and condition assessment of bronchial asthma complicated by infection in children.

关 键 词：支气管哮喘 感染 CD25 CRP TLRS 

分 类 号：R725.6[医药卫生—儿科]