6620例已婚妇女HPV感染现状及影响因素分析  

Analysis of current status and influencing factors of HPV infection in 6 620 married women

作　　者：岳帆 侯向萍 咸敏[1] 魏策[1] YUE Fan;HOU Xiangping;XIAN Min;WEI Ce(Department of Laboratory Medicine,Alar Hospital,First Division,Xinjiang Production and Construction Corps,Aral,Xinjiang,China,843300)

机构地区：[1]新疆生产建设兵团第一师阿拉尔医院检验科,新疆阿拉尔843300

出　　处：《分子诊断与治疗杂志》2022年第3期512-515,520,共5页Journal of Molecular Diagnostics and Therapy

摘　　要：目的 通过对阿尔拉片区35~60周岁已婚健康妇女进行人乳头瘤病毒筛查,了解其感染状况,进一步分析其影响因素。方法 选取2020年5月至2021年4月间阿尔拉片区35~60周岁已婚健康妇女6 620例为研究对象,采用荧光PCR-反向点杂交法进行HPV核酸检测及基因分型;采用女性人乳头瘤病毒感染影响因素调查问卷调查女性人乳头瘤病毒感染影响因素。结果 在受检的6 620名妇女中,共检出HPV阳性感染率为14.34%(949/6 620),其中高危型阳性率为10.09%(668/6 620),低危型阳性率2.34%(155/6 620),合并型阳性率1.90%(126/6 620),混合感染中以二重感染及三重感染最为常见;在高危型感染人群中,HPV亚型感染排在前3位依次为HPV52,HPV16,HPV58,在低危型感染人群中,以HPV54,HPV61最为常见;女性HPV感染与否在初次性生活年龄、文化程度、吸烟、性生活频率、性伴侣人数、避孕套使用、同房后清洗行为、宫颈糜烂程度、免疫力低下等方面比较,差异有统计学意义(P<0.05),在结婚次数、饮酒、人工流产次数、规律体育锻炼等方面比较,差异无统计学意义(P>0.05);logistics回归分析显示,初次性生活年龄≤20岁(OR=1.940)、性生活频率≥4次/周(OR=1.814)、重度宫颈糜烂(OR=1.598)、吸烟(OR=1.509)、免疫力低下(OR=1.371)是女性人乳头瘤病毒感染的独立危险因素。结论 阿拉尔片区女性HPV高危感染亚型主要以HPV52、HPV16、HPV58为主。其中性生活过早、性生活频率高、吸烟等是女性人乳头瘤病毒感染危险因素。有关部门应依据上述危险因素合理制定有效干预措施,大力宣传人乳头瘤病毒和疫苗的健康宣传教育工作,降低本地区女性人乳头瘤病毒感染率。Objective To understand the infection status of human papillomavirus by screening healthy married women aged 35 to 60 in Arla area,and further analyze its influencing factors. Methods From May 2020 to April 2021,6 620 healthy married women aged 35 to 60 in the Arla area were selected as the research subjects. HPV nucleic acid detection and genotyping were performed by fluorescent PCR-reverse dot blot;female Questionnaire on influencing factors of human papillomavirus infection to investigate the influencing factors of human papillomavirus infection in women. Results Among the 6 620 women examined,the positive rate of HPV infection was 14.34%(949/6 620),of which the positive rate of high-risk type was10.09%(668/6 620),and the positive rate of low-risk type was 2.34%.(155/6 620),the combined type positive rate was 1.90%(126/6 620),superinfection and triple infection were the most common in mixed infection;in high-risk infection population,HPV subtype infection ranked the top 3 in order HPV52,HPV16,and HPV58. Among the low-risk types of infection,HPV54 and HPV61 are the most common. Whether women are infected with HPV is related to age at first sexual life,educational level,smoking,frequency of sexual life,number of sexual partners,condom use,There were statistically significant differences in cleaning behavior after intercourse,cervical erosion degree,and low immunity(P<0.05),but there was no significant difference in the number of marriages,drinking,number of induced abortions,and regular physical exercise(P<0.05);logistic regression analysis showed that the age of first sexual intercourse was ≤20 years old(OR=1.940),the frequency of intercourse was ≥4 times/week(OR=1.814),severe cervical erosion(OR=1.598),smoking(OR=1.509) and low immunity(OR=1.371) were independent risk factors for HPV infection in women.Conclusion The high-risk HPV infection subtypes of females in Alar area are mainly HPV52,HPV16 and HPV58. Among them,early sexual life,high frequency of sexual life and smoking are the risk factors for femal

关 键 词：HPV感染 荧光PCR-反向点杂交法 育龄妇女 影响因素 

分 类 号：R737.33[医药卫生—肿瘤]