血浆CD100在鼻咽癌预后中的意义  

Prognostic Value of Plasma CD100 in Nasopharyngeal Carcinoma

作　　者：郑燕平 孙鸣[2] 王筱雯 沈关心[4] 胡斌[1,5] ZHENG Yanping;SUN Ming;WANG Xiaowen;SHEN Guanxin;HU Bin(Clinical Laboratory of Cancer Center,the First Affiliated Hospital of Xiamen University,Xiamen,Fujian,361003,China;Department of Reproductive Medicine,the First Affiliated Hospital of Xiamen University,Xiamen,Fujian,361003,China;Department of Infectious Disease,the First Affiliated Hospital of Xiamen University,Xiamen,Fujian,361003,China;Department of Immunology,School of Basic Medicine,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430030,China;Department of Clinical Laboratory,the First Affiliated Hospital of Xiamen University,Xiamen,Fujian,361003,China)

机构地区：[1]厦门大学附属第一医院肿瘤中心实验室,福建省厦门市361003 [2]厦门大学附属第一医院生殖医学科,福建省厦门市361003 [3]厦门大学附属第一医院感染科,福建省厦门市361003 [4]华中科技大学同济医学院基础医学院免疫学系,武汉市430030 [5]厦门大学附属第一医院检验科,福建省厦门市361003

出　　处：《医学分子生物学杂志》2022年第2期105-109,共5页Journal of Medical Molecular Biology

基　　金：福建省自然科学基金卫生联合项目(No.2021J011355),福建省卫健委医学创新课题(No.2018-CXB-25),福建省卫生健康中青年领军人才项目。

摘　　要：目的评估血浆CD100浓度与鼻咽癌复发或转移及其预后相关性,并探讨其作为预测鼻咽癌预后标志物的可行性。方法酶联免疫吸附试验(Elisa)测定60例入院时未经治疗的鼻咽癌患者和23例健康受试者血浆CD100浓度,荧光定量PCR检测血浆EBV-DNA载量。统计分析鼻咽癌患者血浆CD100浓度与预后的关系。结果鼻咽癌患者血浆CD100浓度高于健康对照组(P<0.0001),并且复发转移组血浆CD100浓度明显高于无复发转移组(P<0.0001);生存分析显示血浆CD100与鼻咽癌5年无进展生存期(PFS)相关(P<0.0001),是鼻咽癌PFS的独立预后因素。结论血浆CD100与鼻咽癌复发、转移密切相关,可作预测预后标志物。Objective To evaluate whether the plasma CD100(pCD100)concentration could predict the clinical outcome of patients with nasopharyngeal carcinoma(NPC).Methods A total of 60 patients and 23 healthy doners were enrolled.Their plasma concentrations of CD100 were measured by ELISA,and EBV DNA loads were detected by real-time PCR.The relationship between pCD100 concentrations and outcomes of NPC patients was analyzed.Results The pCD100 concentrations were higher in NPC patients than in health controls(P<0.0001).In addition,the pCD100 concentrations were significantly elevated in NPC patients with recurrence or metastasis than those without recurrent and metastasis(P<0.0001).Cox analysis showed that the concentration of pCD100 was associated with 5-year progression-free survival(PFS)rate in NPC patients(P<0.0001),and was an independent prognostic factor for PFS of NPC patients.Conclusion The pCD100 concentration is associated with NPC recurrence or metastasis and could be a potential noninvasive prognostic marker for NPC.

关 键 词：血浆 CD100 鼻咽癌 复发 转移 生物标志物 

分 类 号：R739.62[医药卫生—肿瘤]