Anti-diabetic effects of linarin from Chrysanthemi Indici Flos via AMPK activation  

作　　者：Zhenji Wang Zhe Bai Jinghua Yan Tengteng Liu Yingmei Li Jiahui Xu Xiaoqian Meng Yuefeng Bi 

机构地区：[1]School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China [2]Collaborative Innovation Center of New Drug Research and Safety Evaluation,Zhengzhou 450001,China

出　　处：《Chinese Herbal Medicines》2022年第1期97-103,共7页中草药（英文版）

基　　金：supported by the National Natural Science Foundation of China (grant numbers 81273392);the Natural Science Foundation of Henan Province (grant numbers 182300410348)

摘　　要：Objective:The purpose of this study is to investigate the anti-diabetic effects of linarin,a flavonoid extracted from Chrysanthemi Indici Flos(CIF),and its potential mechanisms.Methods:The effects of linarin on cell viability and glucose consumption in Hep G2 cells were measured.Meanwhile,monosodium glutamate(MSG) mouse model was constructed to monitor the changes of insulin tolerance,glucose tolerance,triglyceride and cholesterol.The protein expression levels of pAMPK,p-ACC,PEPCK and p-GS were detected by Western blot.Results:Linarin could increase the relative glucose consumption of Hep G2 cells,improve insulin tolerance and glucose tolerance,and decrease the levels of triglyceride and cholesterol of MSG mice.Simultaneously,the expression levels of p-AMPK and p-ACC in Hep G2 cells and the liver tissue of MSG mice were increased,while the expression levels of PEPCK and p-GS were decreased after treatment with linarin.Conclusion:Insulin resistance could be ameliorated by linarin in type 2 diabetes,and its mechanism may be related to AMPK signaling pathway.

关 键 词：AMPK anti-diabetes Chrysanthemi Indici Flos insulin resistance LINARIN type 2 diabetes 

分 类 号：R285.5[医药卫生—中药学]