Severe tinnitus and migraine headache in a 37-year-old woman treated with trastuzumab for breast cancer:A case report  

作　　者：Yong-Zhi Liu Hai Jiang Yong-Hua Zhao Qi Zhang Shi-Chao Hao Li-Ping Bao Wei Wu Zhao-Bo Jia Hui-Chuan Jiang 

机构地区：[1]Department of Breast Surgery,General Hospital of Benxi Iron&Steel Industry Group of Liaoning Health Industry Group,Benxi 117000,Liaoning Province,China

出　　处：《World Journal of Clinical Cases》2022年第8期2491-2496,共6页世界临床病例杂志

摘　　要：BACKGROUND Trastuzumab is a generally safe agent prescribed in the systemic treatment of breast cancer.Tinnitus is not a currently known adverse event related to trastuzumab.Here,we describe a rare case of severe tinnitus and a migraine headache induced by trastuzumab used for adjuvant therapy.CASE SUMMARY A 37-year-old woman was diagnosed with hormone receptor-positive and human epidermal growth factor receptor 2-positive breast cancer.After surgery,she was treated with four cycles of epirubicin and cyclophosphamide;she then received docetaxel and a loading dose of trastuzumab plus pertuzumab.Less than half an hour after trastuzumab infusion,the patient complained of severe tinnitus and left-sided migraine headache.Trastuzumab monotherapy was discontinued immediately,and symptoms disappeared after 10 min.Trastuzumab was readministered,and severe tinnitus and migraine headache recurred.Trastuzumab was stopped,and severe tinnitus diminished after 10 min.Pertuzumab and docetaxel therapy was then administered,and no adverse events were observed.Subsequent infusions of trastuzumab every three weeks did not show the same symptoms.CONCLUSION Although trastuzumab is well-tolerated in most patients,we should pay attention to the risk of severe tinnitus and migraine.

关 键 词：Breast cancer TINNITUS Adverse effects TRASTUZUMAB Migraine headache Case report 

分 类 号：R737.9[医药卫生—肿瘤]