Management of incidentally discovered appendiceal neuroendocrine tumors after an appendicectomy  

作　　者：JoséLuis Muñoz de Nova Jorge Hernando Miguel Sampedro Núñez Greissy Tibisay Vázquez Benítez Eva María Triviño Ibáñez María Isabel del Olmo García Jorge Barriuso Jaume Capdevila Elena Martín-Pérez 

机构地区：[1]Department of General and Digestive Surgery,Hospital Universitario de La Princesa,Madrid 28006,Spain [2]Department of Surgery,Universidad Autónomade Madrid,Madrid 28029,Spain [3]Gastrointestinal and Endocrine Tumor Unit,Medical Oncology Department,Vall d´Hebron University Hospital,Vall d´Hebron Institute of Oncology,Barcelona 08035,Spain [4]Department of Endocrinology and Nutrition,Hospital Universitario de La Princesa,Madrid 28006,Spain [5]Department of Pathology,Hospital Universitario Puerta de Hierro,Madrid 28222,Spain [6]Department of Pathology,Universidad Autónoma de Madrid,Madrid 28029,Spain [7]Department of Nuclear Medicine,Virgen de las Nieves University Hospital,Granada 18014,Spain [8]Department of Endocrinology and Nutrition,Hospital Universitario i Politècnic La Fe,Valencia 46023,Spain [9]Division of Cancer Sciences,School of Medical Sciences,Faculty of Biology,Medicine and Health,University of Manchester,Manchester M139PL,United Kingdom [10]Department of Medical Oncology,The Christie NHS Foundation Trust,Manchester M204BX,United Kingdom

出　　处：《World Journal of Gastroenterology》2022年第13期1304-1314,共11页世界胃肠病学杂志（英文版）

摘　　要：Appendiceal neuroendocrine tumors(aNETs)are an uncommon neoplasm that is relatively indolent in most cases.They are typically diagnosed in younger patients than other neuroendocrine tumors and are often an incidental finding after an appendectomy.Although there are numerous clinical practice guidelines on management of a NETs,there is continues to be a dearth of evidence on optimal treatment.Management of these tumors is stratified according to risk of locoregional and distant metastasis.However,there is a lack of consensus regarding tumors that measure 1-2 cm.In these cases,some histopathological features such as size,tumor grade,presence of lymphovascular invasion,or mesoappendix infiltration must also be considered.Computed tomography or magnetic resonance imaging scans are recommended for evaluating the presence of additional disease,except in the case of tumors smaller than 1 cm without additional risk factors.Somatostatin receptor scintigraphy or positron emission tomography with computed tomography should be considered in cases with suspected residual or distant disease.The main point of controversy is the indication for performing a completion right hemicolectomy after an initial appendectomy,based on the risk of lymph node metastases.The main factor considered is tumor size and 2 cm is the most common threshold for indicating a colectomy.Other factors such as mesoappendix infiltration,lymphovascular invasion,or tumor grade may also be considered.On the other hand,potential complications,and decreased quality of life after a hemicolectomy as well as the lack of evidence on benefits in terms of survival must be taken into consideration.In this review,we present data regarding the current indications,outcomes,and benefits of a colectomy.

关 键 词：Neuroendocrine tumors Carcinoid tumor Appendiceal neoplasms COLECTOMY Neoplasm grading Treatment outcome 

分 类 号：R73[医药卫生—肿瘤]