Association of chronic obstructive pulmonary disease with mild cognitive impairment and dementia risk:A systematic review and meta-analysis  

作　　者：Li-Ying Zhao Xue-Lai Zhou 

机构地区：[1]Department of Geriatrics,Traditional Chinese Medical Hospital of Zhuji,Zhuji 311800,Zhejiang Province,China [2]Department of Respiratory Medicine,Traditional Chinese Medical Hospital of Zhuji,Zhuji 311800,Zhejiang Province,China

出　　处：《World Journal of Clinical Cases》2022年第11期3449-3460,共12页世界临床病例杂志

摘　　要：BACKGROUND Chronic obstructive pulmonary disease(COPD)is a common public health issue that has been linked to cognitive dysfunction.AIM To investigate the relationship between COPD and a risk of mild cognitive impairment(MCI)and dementia.METHODS A comprehensive literature search of the PubMed,Embase,Google Scholar,and Cochrane Library electronic databases was conducted.Pooled odds ratios(OR)and mean differences(MD)with 95%confidence intervals(CIs)were calculated using a random or fixed effects model.Studies that met the inclusion criteria were assessed for quality using the Newcastle Ottawa Scale.RESULTS Twenty-seven studies met all the inclusion criteria.Meta-analysis yielded a strong association between COPD and increased risk of MCI incidence(OR=2.11,95%CI:1.32-3.38).It also revealed a borderline trend for an increased dementia risk in COPD patients(OR=1.16,95%CI:0.98-1.37).Pooled hazard ratios(HR)using adjusted confounders also showed a higher incidence of MCI(HR=1.22,95%CI:-1.18 to-1.27)and dementia(HR=1.32,95%CI:-1.22 to-1.43)in COPD patients.A significant lower mini-mental state examination score in COPD patients was noted(MD=-1.68,95%CI:-2.66 to-0.71).CONCLUSION Our findings revealed an elevated risk for the occurrence of MCI and dementia in COPD patients.Proper clinical management and attention are required to prevent and control MCI and dementia incidence in COPD patients.

关 键 词：Mild cognitive impairment Chronic obstructive pulmonary disease DEMENTIA META-ANALYSIS 

分 类 号：R563.9[医药卫生—呼吸系统] R749.1[医药卫生—内科学]