Abnormal synaptic plasticity and impaired cognition in schizophrenia  

作　　者：Xiu-Lin Wu Qiu-Jin Yan Fan Zhu 

机构地区：[1]State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology,Department of Medical Microbiology,School of Medicine,Wuhan University,Wuhan 430071,Hubei Province,China

出　　处：《World Journal of Psychiatry》2022年第4期541-557,共17页世界精神病学杂志

基　　金：Supported by National Natural Science Foundation of China,No. 81971943, No. 81772196, No. 31470264, No. 81271820, No. 30870789 and No. 30300117;Stanley Foundation from the Stanley Medical Research Institute (SMRI),United States,No. 06R-1366 (to Dr. Zhu F);Medical Science Advancement Program (Basic Medical Sciences) of Wuhan University,No. TFJC 2018002

摘　　要：Schizophrenia(SCZ)is a severe mental illness that affects several brain domains with relation to cognition and behaviour.SCZ symptoms are typically classified into three categories,namely,positive,negative,and cognitive.The etiology of SCZ is thought to be multifactorial and poorly understood.Accumulating evidence has indicated abnormal synaptic plasticity and cognitive impairments in SCZ.Synaptic plasticity is thought to be induced at appropriate synapses during memory formation and has a critical role in the cognitive symptoms of SCZ.Many factors,including synaptic structure changes,aberrant expression of plasticityrelated genes,and abnormal synaptic transmission,may influence synaptic plasticity and play vital roles in SCZ.In this article,we briefly summarize the morphology of the synapse,the neurobiology of synaptic plasticity,and the role of synaptic plasticity,and review potential mechanisms underlying abnormal synaptic plasticity in SCZ.These abnormalities involve dendritic spines,postsynaptic density,and long-term potentiation-like plasticity.We also focus on cognitive dysfunction,which reflects impaired connectivity in SCZ.Additionally,the potential targets for the treatment of SCZ are discussed in this article.Therefore,understanding abnormal synaptic plasticity and impaired cognition in SCZ has an essential role in drug therapy.

关 键 词：SCHIZOPHRENIA Synaptic plasticity Synaptic structure Synaptic transmission Cognitive dysfunction ABNORMALITY 

分 类 号：R749.3[医药卫生—神经病学与精神病学]