B cells in pancreatic cancer stroma  

作　　者：Francesca Romana Delvecchio Michelle R Goulart Rachel Elizabeth Ann Fincham Michele Bombadieri Hemant M Kocher 

机构地区：[1]William Harvey Research Institute,Queen Mary University of London,London EC1M 6BQ,United Kingdom [2]Barts Cancer Institute,Queen Mary University of London,London EC1M 6BQ,United Kingdom [3]Barts and the London HPB Centre,Barts Health NHS Trust,London E11BB,United Kingdom

出　　处：《World Journal of Gastroenterology》2022年第11期1088-1101,共14页世界胃肠病学杂志（英文版）

基　　金：Supported by Francesca Romana Delvecchio is supported by Cancer Research UK Post-doctoral fellowship;Michelle Goulart is supported by PCRF post-doctoral fellowship;Rachel Elizabeth Ann Fincham is supported by PhD studentship awarded by Barts Charity(London,UK)and A^(*)STAR(Singapore)。

摘　　要：Pancreatic cancer is a disease with high unmet clinical need.Pancreatic cancer is also characterised by an intense fibrotic stroma,which harbours many immune cells.Studies in both human and animal models have demonstrated that the immune system plays a crucial role in modulating tumour onset and progression.In human pancreatic ductal adenocarcinoma,high B-cell infiltration correlates with better patient survival.Hence,B cells have received recent interest in pancreatic cancer as potential therapeutic targets.However,the data on the role of B cells in murine models is unclear as it is dependent on the pancreatic cancer model used to study.Nevertheless,it appears that B cells do organise along with other immune cells such as a network of follicular dendritic cells(DCs),surrounded by T cells and DCs to form tertiary lymphoid structures(TLS).TLS are increasingly recognised as sites for antigen presentation,T-cell activation,Bcell maturation and differentiation in plasma cells.In this review we dissect the role of B cells and provide directions for future studies to harness the role of B cells in treatment of human pancreatic cancer.

关 键 词：B cells Pancreatic cancer Cancer immunology Tertiary lymphoid structures Anti-tumour immunoglobulins Plasma cells 

分 类 号：R735.9[医药卫生—肿瘤]