Realgar(α-As_(4)S_(4))Treats Myelodysplastic Syndromes through Reducing DNA Hypermethylation  

作　　者：ZHANG Miao ZHANG Jia-yi SUN Ming-qian LU Peng LIU Jian-xun 

机构地区：[1]Research Center,Xiyuan Hospital,China Academy of Chinese Medical Sciences and Beijing Key Lab of Traditional Chinese Medicine Pharmacology,Beijing(100091),China [2]Education Sector,Xiyuan Hospital,China Academy ofChinese Medical Sciences,Beijing(100091),China [3]MedicalAdministration Division,Xiyuan Hospital,China Academy ofChinese Medical Sciences,Beijing(100091),China

出　　处：《Chinese Journal of Integrative Medicine》2022年第3期281-288,共8页中国结合医学杂志（英文版）

摘　　要：DNA hypermethylation is an epigenetic modification that plays a critical role in the oncogenesis of myelodysplastic syndromes(MDS).Aberrant DNA methylation represses the transcription of promotors of tumor suppressor genes,inducing gene silencing.Realgar(α-As_(4)S_(4))is a traditional medicine used for the treatment of various diseases in the ancient time.Realgar was reported to have efficacy for acute promyelocytic leukemia(APL).It has been demonstrated that realgar could efficiently reduce DNA hypermethylation of MDS.This review discusses the mechanisms of realgar on inhibiting DNA hypermethylation of MDS,as well as the species and metabolisms of arsenic in vivo.

关 键 词：myelodysplastic syndromes DNA hypermethylation REALGAR ARSENIC REVIEW 

分 类 号：R551.3[医药卫生—血液循环系统疾病]