REALGAR

作品数：36被引量：111H指数：6
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相关领域：医药卫生更多>>
相关作者：刘文龙张天蓝苟宝迪王聪袁丽佳更多>>
相关机构：北京大学湖南中医药大学中国医科大学商务印书馆更多>>
相关期刊：《Neural Regeneration Research》《矿物学报》《World Journal of Traditional Chinese Medicine》《Journal of Pharmaceutical Analysis》更多>>
相关基金：国家自然科学基金广西壮族自治区自然科学基金国家教育部博士点基金更多>>
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Realgar-indigo naturalis formula for the treatment of patients with relapsed and arsenic trioxide-resistant acute promyelocytic leukemia:A case series
《Journal of Integrative Medicine》2024年第5期614-620,共7页Yong-guang Fang Shi-lin Huang Nan-nan Chen 
Introduction There is currently no standard treatment for relapsed and arsenic trioxide(ATO)-resistant acute promyelocytic leukemia(APL).Here,we report a case series of realgar-indigo naturalis formula(RIF)for the suc...
关键词：Acute promyelocytic leukemia Realgar-indigo naturalis formula Arsenic Trioxide RESISTANT Case report 
Realgar toxicity in terms of its chemical characterization, pharmacological mechanisms, and metabolic profile: A review
《Science of Traditional Chinese Medicine》2023年第1期50-58,共9页Yan Yi Chunying Li Yong Zhao Aihua Liang 
This work was supported by grants from China Academy of Chinese Medical Sciences Innovation Fund(CI2021B016,CI2021A04801);the National Natural Science Foundation of China(82192913,82174073);the China Academy of Chinese Medical Sciences Foundation(ZZ-13-035-10,ZXKT20022,ZZ14-YQ-026);the Qihuang Scholar Program.
Realgar is an arsenic-containing Chinese medicine known for its toxin-removing,phlegm-dispelling,and malaria-intercepting effects.It has proven to be effective in the treatment of acute promyelocytic leukemia.However,...
关键词：Arsenic species METHYLATION Oxidative stress PHARMACOLOGY REALGAR TOXICITY 
Acid Water-ground Nano-realgar Is Superior to Crude Realgar in Promoting Apoptosis of MCF-7 Breast Cancer Cells被引量：2
《Current Medical Science》2022年第4期720-732,共13页Juan XI Jia-hui FANG Xiao-mei XIONG Chun GUI Yu-xue WANG Xiu-qiao ZHANG 
supported by the Science and Technology_Research Project of Hubei Education Department(No.B2019097).
Objective:Realgar is a traditional mineral Chinese medicine with antitumor effects,but it has high toxicity and low efficacy in its crude form.The purpose of this study was to optimize realgar to increase its efficacy...
关键词：REALGAR acid water-ground nano-realgar MCF-7 cells APOPTOSIS 
Realgar(α-As_(4)S_(4))Treats Myelodysplastic Syndromes through Reducing DNA Hypermethylation被引量：2
《Chinese Journal of Integrative Medicine》2022年第3期281-288,共8页ZHANG Miao ZHANG Jia-yi SUN Ming-qian LU Peng LIU Jian-xun 
DNA hypermethylation is an epigenetic modification that plays a critical role in the oncogenesis of myelodysplastic syndromes(MDS).Aberrant DNA methylation represses the transcription of promotors of tumor suppressor ...
关键词：myelodysplastic syndromes DNA hypermethylation REALGAR ARSENIC REVIEW 
Safety and efficacy of Compound Huangdai Tablets combined with all-trans retinoic acid for treatment of acute promyelocytic leukemia:Clinical evidence and potential mechanisms被引量：3
《Chinese Herbal Medicines》2022年第1期154-165,共12页Qianqian Huang Tao Wang Yan Xiong Liping Qu Qiaozhi Yin Wenjun Zou 
funded by the China Postdoctoral Science(No.2018M633332)
Objective:To evaluate the safety and efficacy of Compound Huangdai Tablets(Realgar-Indigo Naturalis formula,RIF)combined with all-trans retinoic acid(ATRA)to treat acute promyelocytic leukemia(APL).Methods:This study ...
关键词：acute promyelocytic leukemia all-trans retinoic acid network pharmacology Realgar-Indigo Naturalis formula 
Arsenic concentration in peripheral blood is correlated with efficacy of a Traditional Chinese Medicine regimen containing realgar for the treatment of myelodysplastic syndromes被引量：4
《Journal of Traditional Chinese Medicine》2021年第4期630-635,共6页WANG Dexiu XU Yonggang DU Yu WANG Hongzhi LI Liu HU Xiaomei YANG Xiupeng MA Rou ZHOU Qingbing 
Supported by China Academy of Chinese Medicine Scientific Foundation(ZZ13-YQ-010);National Natural Science Foundation of China(No.81603490);State Administration of Traditional Chinese Medicine Foundation(No.JDZX-2015264)。
OBJECTIVE:To explore the relationship between the efficacy of realgar for the treatment of myelodysplastic syndromes with multilineage dysplasia(MDS-MLD)and arsenic concentration in the peripheral blood of patients.ME...
关键词：REALGAR ARSENIC myelodysplastic syndromes multiline dysplasia 
High-pressure investigations on the isostructural phase transition and metallization in realgar with diamond anvil cells被引量：1
《Geoscience Frontiers》2021年第2期1031-1037,共7页Linfei Yang Lidong Dai Heping Li Haiying Hu Meiling Hong Xinyu Zhang Pengfei Liu 
the strategic priority Research Program(B)of the Chinese Academy of Sciences(Grant No.18010401);Key Research Program of Frontier Sciences of CAS(Grant No.QYZDB-SSW-DQC009);Hundred Talents Program of CAS,NSF of China(Grant Nos.41774099 and 41772042);Youth Innovation Promotion Association of CAS(Grant No.2019390);Special Fund of the West Light Foundation of CAS;the Supercomputer Center of Fujian Institute of Research on the Structure of Matter(FJIRSM)is acknowledged.
The high-pressure structural,vibrational and electrical properties for realgar were investigated by in-situ Raman scattering and electrical conductivity experiments combined with first-principle calculations up to~30....
关键词：REALGAR Isostructural phase transition METALLIZATION Raman spectroscopy Electrical conductivity High pressure 
Arsenic-Containing Qinghuang Powder(青黄散)Is An Alternative Treatment for Elderly Acute Myeloid Leukemia Patients Refusing Low-Intensity Chemotherapy被引量：4
《Chinese Journal of Integrative Medicine》2020年第5期339-344,共6页FAN Teng QUAN Ri-cheng LIU Wei-yi XIAO Hai-yan TANG Xu-dong LIU Chi LI Liu LV Yan WANG Hong-zhi XU Yong-gang GUO Xiao-qing HU Xiao-mei 
Supported by Special Grants of Clinical Research Base of Traditional Chinese Medicine,State Administration of Traditional Chinese Medicine(No.JDZX2012180)。
Objective:To analyze the overall survival(OS)of elderly acute myeloid leukemia(AML)patients treated with oral arsenic-containing Qinghuang Powder(青黄散,QHP)or low-intensity chemotherapy(LIC).Methods:Forty-two elderly...
关键词：acute MYELOID LEUKEMIA Qinghuang Powder REALGAR arsenic ELDERLY patient Chinese medicine 
Liver metabonomics study on the protective effect of glycyrrhetinic acid against realgar-induced liver injury被引量：5
《Chinese Journal of Natural Medicines》2020年第2期138-147,共10页HUO Tao-Guang FANG Ying ZHANG Ying-Hua FENG Cong JIANG Hong 
This work was supported by the National Natural Science Foundation of China(Nos.81403066 and 81473417).
Glycyrrhetinic acid(GA)is the bioactive ingredient in Glycyrrhizae Radix et Rhizoma.Our previous study has reported that GA has protective effect on realgar-induced hepatotoxicity.However,the details of the hepatoprot...
关键词：METABONOMICS Glycyrrhetinic ACID REALGAR LIVER UPLC-MS 
Advances in the Safety Evaluation of Mineral Medicines-Cinnabar and Realgar被引量：6
《World Journal of Traditional Chinese Medicine》2019年第3期164-172,共9页Jing-Zhuo Tian Ai-Hua Liang Xiao-Xin Zhu Yong Zhao Yan Yi Chun-Ying Li Jia-Yin Han 
supported by grants from the National Science and Technology Major Project (2015ZX09501004-003-001);the Beijing Science and Technology Projects (Z151100000115012, Z161100004916025);the China Academy of Chinese Medical Sciences Foundation (ZZ10-025);the National Public Welfare Industry Research Projects (201507004)
Mineral medicines have a long history in the treatment of diseases. Among these, cinnabar and realgar are the most commonly used. This review discusses the differences between cinnabar and realgar and other mercurials...
关键词：CINNABAR COMPOUND Chinese MEDICINES DISPOSITION REALGAR TOXICITY 
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