Relationship between treatment types and blood–brain barrier disruption in patients with acute ischemic stroke:Two case reports  

作　　者：Youngbeom Seo Jonghoon Kim Min Cheol Chang Hyungkyu Huh Eun-Hee Lee 

机构地区：[1]Department of Neurosurgery,College of Medicine,Yeungnam University,Daegu 42415,South Korea [2]Department of Rehabilitation Medicine,College of Medicine,Yeungnam University,Daegu 42415,South Korea [3]Medical Interdisciplinary Team,Medical Device Development Center,Daegu-Gyeongbuk Medical Innovation Foundation,Daegu 41061,South Korea

出　　处：《World Journal of Clinical Cases》2022年第7期2351-2356,共6页世界临床病例杂志

基　　金：Supported by the National Research Foundation of Korea grant,No.2019M3E5D1A02069399

摘　　要：BACKGROUND Blood-brain barrier(BBB)disruption plays an important role in the development of neurological dysfunction in ischemic stroke.However,diagnostic modalities that can clearly diagnose the degree of BBB disruption in ischemic stroke are limited.Here,we describe two cases in which the usefulness of dynamic contrastenhanced magnetic resonance imaging(DCE-MRI)in detecting BBB disruption was evaluated after treatment of acute ischemic stroke using two different methods.CASE SUMMARY The two patients of similar age and relatively similar cerebral infarction locations were treated conservatively or with thrombectomy,although their sex was different.As a result of analysis by performing DCE-MRI,it was confirmed that BBB disruption was significantly less severe in the patient who underwent thrombectomy(P=3.3×10^(-7)),whereas the average Ktrans of the contralateral hemisphere in both patients was similar(2.4×10^(-5)min^(-1) and 2.0×10^(-5)min^(-1)).If reperfusion is achieved through thrombectomy,it may indicate that the penumbra can be saved and BBB recovery can be promoted.CONCLUSION Our cases suggest that BBB disruption could be important if BBB permeability is used to guide clinical treatment.

关 键 词：Blood-brain barrier Ischemic stroke Dynamic contrast-enhanced magnetic resonance imaging THROMBECTOMY PENUMBRA Case report 

分 类 号：R743.3[医药卫生—神经病学与精神病学]