Mycobacterium tuberculosis bacteremia in a human immunodeficiency virus-negative patient with liver cirrhosis:A case report  

作　　者：Zhe-Zhe Lin Dan Chen Sai Liu Jian-Hua Yu Shou-Rong Liu Ming-Li Zhu 

机构地区：[1]Department of Open Laboratory Medicine,Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University,Hangzhou 310000,Zhejiang Province,China [2]Department of Infectious Diseases,Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University,Hangzhou 310000,Zhejiang Province,China [3]Department of Hepatology,Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University,Hangzhou 310000,Zhejiang Province,China

出　　处：《World Journal of Clinical Cases》2022年第10期3284-3290,共7页世界临床病例杂志

摘　　要：BACKGROUND With the increasing prevalence of human immunodeficiency virus(HIV),the incidence of Mycobacterium tuberculosis(M.tuberculosis)bacteremia has also increased.As a common affliction of acquired immunodeficiency syndrome patients,M.tuberculosis infection is associated in these patients with severe sepsis and high mortality.In contrast,M.tuberculosis bacteremia is rarely seen in HIVnegative patients,and M.tuberculosis has never been reported from the blood of patients with liver cirrhosis.CASE SUMMARY We evaluated a 55-year-old Chinese male patient who had been admitted to the hospital with abdominal distension of unknown cause of one-week duration,accompanied by diarrhea,shortness of breath,and occasional fever.Based on these indicators of abnormal inflammation and fever,we suspected the presence of an infection.Although evidence of microbial infection was not found in routine clinical tests and the patient did not show typical clinical symptoms of infection with M.tuberculosis,next-generation sequencing of blood samples nevertheless demonstrated the presence of M.tuberculosis,which was subsequently isolated from blood samples grown in conventional Bac T/ALERT FA blood culture bottles.CONCLUSION Our findings demonstrate that HIV-negative liver cirrhosis patients can also be infected with M.tuberculosis.

关 键 词：Mycobacterium tuberculosis BACTEREMIA Human immunodeficiency virus Liver cirrhosis High-throughput nucleotide sequencing Case report 

分 类 号：R575.2[医药卫生—消化系统] R515.3[医药卫生—内科学]