Dedifferentiated chondrosarcoma of the middle finger arising from a solitary enchondroma:A case report  

作　　者：Hirotaka Yonezawa Norio Yamamoto Katsuhiro Hayashi Akihiko Takeuchi Shinji Miwa Kentaro Igarashi Sei Morinaga Yohei Asano Shiro Saito Yasunori Tome Hiroko Ikeda Takayuki Nojima Hiroyuki Tsuchiya 

机构地区：[1]Department of Orthopaedic Surgery,Graduate School of Medical Sciences,Kanazawa University,Kanazawa 920-8641,Ishikawa,Japan [2]Department of Orthopedic Surgery,Graduate School of Medicine,University of the Ryukyus,Nishihara 903-0215,Okinawa,Japan [3]Department of Diagnostic Pathology,Kanazawa University Hospital,Kanazawa 920-8641,Ishikawa,Japan

出　　处：《World Journal of Clinical Cases》2022年第10期3297-3305,共9页世界临床病例杂志

摘　　要：BACKGROUND Dedifferentiated chondrosarcoma(DDCS)accounts for 10%of all chondrosarcomas and has the poorest outcome,with a 5-year survival rate of 7%-25%.DDCS commonly occurs in the femur and pelvis,whereas DDCS of the finger is extremely rare.Furthermore,the histological findings of preexisting solitary enchondroma samples are important and valuable for diagnosing malignant transformations.CASE SUMMARY We report our experience with DDCS in the proximal phalanx of the left middle finger of an 87-year-old woman.She had undergone surgery for enchondroma,with curettage and artificial bone grafting,11 years ago,in the same location.Several years after the primary surgery,the left middle finger gradually started to enlarge,and the growth speed increased in the past year.Plain radiographs showed an expansive osteolytic lesion with calcifications and residual grafting material.Owing to the suspicion of malignancy,we performed ray amputation.Histological findings revealed an abrupt transition between the low-grade chondrosarcoma and dedifferentiated sarcoma components.The dedifferentiated components showed the features of a high-grade undifferentiated pleomorphic sarcoma.The patient was diagnosed with DDCS arising from a preexisting enchondroma.She had no local recurrence or distant metastasis and died of pneumonia 6 years and 10 months after the second surgery.CONCLUSION The histological findings of a precursor lesion showed a typical enchondroma,suggesting that DDCS can arise from enchondroma.

关 键 词：Dedifferentiated chondrosarcoma ENCHONDROMA FINGER PHALANX Ray amputation Case report 

分 类 号：R738.3[医药卫生—肿瘤]