Clinical high-risk criteria of psychosis in 8–17-year-old community subjects and inpatients not suspected of developing psychosis  

作　　者：Frauke Schultze-Lutter Petra Walger Maurizia Franscini Nina Traber-Walker Naweed Osman Helene Walger Benno G Schimmelmann Rahel Flückiger Chantal Michel 

机构地区：[1]Department of Psychiatry and Psychotherapy,Medical Faculty,Heinrich-Heine University,Düsseldorf 40629,North-Rhine Westphalia,Germany [2]Department of Psychology,Faculty of Psychology,Airlangga University,Surabaya 60286,Indonesia [3]University Hospital of Child and Adolescent Psychiatry and Psychotherapy,University of Bern,Bern 3000,Switzerland [4]Department of Child and Adolescent Psychiatry and Psychotherapy,University of Zürich,Zürich 8032,Germany [5]Department of Psychiatry and Psychotherapy,Ludwig-Maximilian-University,Munich 80336,Bavaria,Germany [6]University Hospital of Child and Adolescent Psychiatry,University Hospital Hamburg-Eppendorf,Hamburg 20246,Germany

出　　处：《World Journal of Psychiatry》2022年第3期425-449,共25页世界精神病学杂志

基　　金：Supported by the conjoint research grant of the Swiss National Science Foundation,SNSF,No. 144100;the German Research Foundation,DFG,No. 231563730, within the Lead Agency Process (SNSF as exclusive evaluating and approving lead agency)

摘　　要：BACKGROUND In children and adolescents compared to adults,clinical high-risk of psychosis(CHR)criteria and symptoms are more prevalent but less psychosis-predictive and less clinically relevant.Based on high rates of non-converters to psychosis,especially in children and adolescents,it was suggested that CHR criteria were:(1)Pluripotential;(2)A transdiagnostic risk factor;and(3)Simply a severity marker of mental disorders rather than specifically psychosis-predictive.If any of these three alternative explanatory models were true,their prevalence should differ between persons with and without mental disorders,and their severity should be associated with functional impairment as a measure of severity.AIM To compare the prevalence and severity of CHR criteria/symptoms in children and adolescents of the community and inpatients.METHODS In the mainly cross-sectional examinations,8–17-year-old community subjects(n=233)randomly chosen from the population register of the Swiss Canton Bern,and inpatients(n=306)with primary diagnosis of attention-deficit/hyperactivity disorder(n=86),eating disorder(n=97),anxiety including obsessive–compulsive disorder(n=94),or autism spectrum disorder(n=29),not clinically suspected to develop psychosis,were examined for CHR symptoms/criteria.Positive items of the Structured Interview for Psychosis-Risk Syndromes(SIPS)were used to assess the symptomatic ultra-high-risk criteria,and the Schizophrenia Proneness Instrument,Child and Youth version(SPI-CY)was used to assess the 14 basic symptoms relevant to basic symptom criteria.We examined group differences in frequency and severity of CHR symptoms/criteria usingχ^(2) tests and nonparametric tests with Cramer’s V and Rosenthal’s r as effect sizes,and their association with functioning using correlation analyses.RESULTS The 7.3%prevalence rate of CHR criteria in community subjects did not differ significantly from the 9.5%rate in inpatients.Frequency and severity of CHR criteria never differed between the community and the four inpatie

关 键 词：Psychotic disorders Risk assessment MINORS COMMUNITY INPATIENTS Psychosocial functioning 

分 类 号：R749[医药卫生—神经病学与精神病学]