Studying the relationship between clinical features and mental health among late-onset myasthenia gravis patients  

作　　者：Lu Yu Li Qiu Hao Ran Qian Ma Ya-Ru Lu Wei-Bin Liu 

机构地区：[1]Department of Neurology,National Key Clinical Department and Key Discipline of Neurology,The First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,Guangdong Province,China [2]School of Pharmaceutical Science,Sun Yat-sen University,Guangzhou 510006,Guangdong Province,China

出　　处：《World Journal of Psychiatry》2022年第3期470-482,共13页世界精神病学杂志

基　　金：Supported by the National Natural Science Foundation of China,No. 81873772 and 81971754;National Natural Science Foundation Key International (Regional) Cooperation Research Project,No. 81620108010;Clinical Study of 5010 Planned Project Sun Yat-sen University,No. 2010003;Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases,No. 2020B1212060017;Guangdong Provincial Clinical Research Center for Neurological Diseases,No. 2020B1111170002;the Southern China International Cooperation Base for Early Intervention and Functional Rehabilitation of Neurological Diseases,No. 2015B050501003 and 2020A0505020004

摘　　要：BACKGROUND Mental disorders are common comorbidities among individuals with neurological diseases, and the prevalence of depressive and anxiety-related symptoms in newly referred patients at neurology outpatient clinics is high. There have been few studies on the mental health of patients with late-onset myasthenia gravis(MG).AIM To examine the relationship between clinical features and the mental health symptoms within late-onset MG patients.METHODS A total of 105 patients diagnosed with MG were recruited consecutively from a neuromuscular outpatient clinic between December 2020 and February 2021. Patients were classified into two groups: early-onset MG(age at onset < 50 years, n = 63) and late-onset MG(age at onset ≥ 50 years, n = 42). Social demographic data and information about marital status, education level, clinical symptoms, serum antibody levels, and therapies used were collected for all participants. Participants were also evaluated using the Myasthenia Gravis Composite scale, the Myasthenia Gravis Activities of Daily Living scale, the Myasthenia Gravis Quality of Life 15(MG-QOL-15) questionnaire, the 17-item version of the Hamilton Depression Rating Scale(HAM-D) and the Hamilton Anxiety Rating Scale(HAM-A). The relationship between clinical features and mental health in late-onset MG patients was examined using multivariate logistic regression analyses.RESULTS Late-onset MG patients were more prone to dyspnea, had higher levels of serum anti-acetylcholine receptor antibodies, and higher total scores on the MG-QOL-15, HAM-D, and HAM-A questionnaires, than early-onset MG patients had(P < 0.05). Among those with late-onset MG, female patients had higher total HAM-D and HAM-A scores than male patients had(P < 0.05). High scores on the QOL-15 questionnaire were associated with higher incidences of anxiety and depression, and the association was found to be independent after adjusting for confounding risk factors. In the late-onset subgroup, the areas under the receiver operating characteristic curves for

关 键 词：Mental health Late-onset myasthenia gravis ANXIETY DEPRESSION 

分 类 号：R746.1[医药卫生—神经病学与精神病学]