Prognostic significance of serum inflammation indices for different tumor infiltrative pattern types of gastric cancer  

作　　者：Yu-Fei Wang Xin Yin Tian-Yi Fang Yi-Min Wang Lei Zhang Xing-Hai Zhang Dao-Xu Zhang Yao Zhang Xi-Bo Wang Hao Wang Ying-Wei Xue 

机构地区：[1]Department of Gastroenterological Surgery,Harbin Medical University Cancer Hospital,Harbin 150081,Heilongjiang Province,China [2]Department of Pathology,Harbin Medical University Cancer Hospital,Harbin 150081,Heilongjiang Province,China

出　　处：《World Journal of Gastrointestinal Oncology》2022年第4期897-919,共23页世界胃肠肿瘤学杂志（英文版）（电子版）

基　　金：Supported by the Harbin Science and Technology Bureau Research and Development Project of Applied Technology,No. 2017RAXXJ054;Nn 10 Program of Harbin Medical University Cancer Hospital,No. Nn 10 PY 2017-03

摘　　要：BACKGROUND Inflammatory indices are considered to be potential prognostic biomarkers for patients with gastric cancer(GC).However,there is no evidence defining the prognostic significance of inflammatory indices for GC with different tumor infiltrative pattern(INF)types.AIM To evaluate the significance of inflammatory indices and INF types in predicting the prognosis of patients with GC.METHODS A total of 962 patients who underwent radical gastrectomy were retrospectively selected for this study.Patients were categorized into the expansive growth type(INFa),the intermediate type(INFb),and the infiltrative growth type(INFc)groups.The cutoff values of inflammatory indices were analyzed by receiver operating characteristic curves.The Kaplan–Meier method and log-rank test were used to analyze overall survival(OS).The chi-square test was used to analyze the association between inflammatory indices and clinical characteristics.The independent risk factors for prognosis in each group were analyzed by univariate and multivariate analyses based on logistic regression.Nomogram models were constructed by R studio.RESULTS The INFc group had the worst OS(P<0.001).The systemic immune-inflammation index(P=0.039)and metastatic lymph node ratio(mLNR)(P=0.003)were independent risk factors for prognosis in the INFa group.The platelet-lymphocyte ratio(PLR)(P=0.018),age(P=0.026),body mass index(P=0.003),and postsurgical tumor node metastasis(pTNM)stage(P<0.001)were independent risk factors for prognosis in the INFb group.The PLR(P=0.021),pTNM stage(P=0.028),age(P=0.021),and mLNR(P=0.002)were independent risk factors for prognosis in the INFc group.The area under the curve of the nomogram model for predicting 5-year survival in the INFa group,INFb group,and INFc group was 0.787,0.823,and 0.781,respectively.CONCLUSION The outcome of different INF types GC patients could be assessed by nomograms based on different inflammatory indices and clinicopathologic features.

关 键 词：Gastric cancer Tumor infiltrative pattern Systemic immune-inflammation index Plateletlymphocyte ratio Prognosis NOMOGRAM 

分 类 号：R735.2[医药卫生—肿瘤]