Role of zonula occludens in gastrointestinal and liver cancers  

作　　者：Amit Kumar Ram Balasubramaniyan Vairappan 

机构地区：[1]Liver Diseases Research Lab,Department of Biochemistry,Jawaharlal Institute of Postgraduate Medical Education and Research,Pondicherry 605006,India

出　　处：《World Journal of Clinical Cases》2022年第12期3647-3661,共15页世界临床病例杂志

基　　金：Supported by JIPMER intramural research grant,Indian Council of Medical Research (ICMR),New Delhi,India,No. 3/1/3 J.R.F.-2016/LS/HRD

摘　　要：A growing body of evidence suggests that tight junction(TJ)proteins play a crucial role in the pathogenesis of various diseases,including gastrointestinal(GI)cancer and hepatocellular carcinoma(HCC).TJ proteins primarily maintain the epithelial and endothelial cells intact together through integral proteins however,recent reports suggest that they also regulate gene expression necessary for cell proliferation,angiogenesis,and metastasis through adapter proteins such as zonula occludens(ZO).ZO proteins are membrane-associated cytosolic scaffolding proteins that modulate cell proliferation by interacting with several transcription factors.Reduced ZO proteins in GI cancer and HCC are correlated with tumor development and poor prognosis.Pubmed has searched for using the keyword ZO and gastric cancer,ZO and cancer,and ZO and HCC for the last ten years to date.This review summarized the role of ZO proteins in cell proliferation and their expression in GI cancer and HCC.Furthermore,therapeutic interventions targeting ZO in GI and liver cancers are reviewed.

关 键 词：Tight junction Zonula occludens-1 Zonula occludens-1 associated nucleic acid binding protein Hepatocellular carcinoma Colon cancer Gastric cancer 

分 类 号：R735[医药卫生—肿瘤]