基于数据挖掘的含佛手临床处方用药规律分析  

Medication Rules of Clinical Prescriptions Containing Citri Sarcodactylis Fructus Based on Data Mining

作　　者：肖倩 郝二伟 杜正彩 吴东阳 梁玲玲 李泽宇 侯小涛 邓家刚 XIAO Qian;HAO Er-wei;DU Zheng-cai;WU Dong-yang;LIANG Ling-ling;LI Ze-yu;HOU Xiao-tao;DENG Jia-gang(Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica,Guangxi University of Chinese Medicine,Collaborative Innovation Center for Research on Functional Ingredients of Agricultural Residues,Guangxi Key Laboratory of TCM Formulas Theory and Transformation for Damp Diseases,Guangxi University of Chinese Medicine,Nanning 530200,China)

机构地区：[1]广西中医药大学广西中药药效研究重点实验室,农作物废弃物功能成分研究协同创新中心,广西中医湿病方药理论与转化重点实验室,南宁530200

出　　处：《中国实验方剂学杂志》2022年第8期194-203,共10页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广西创新驱动发展专项资金项目(桂科AA19254033;桂科AA18118049);中国科学院科技服务网络计划(STS)项目(KFJSTS-QYZD-200-04)。

摘　　要：目的:从含佛手临床处方中挖掘佛手中医用药规律,为佛手现代临床应用、保健产品开发及新药研发提供依据。方法:以中国知网、万方、维普数据库为数据来源,检索收集含佛手的临床处方,运用中医传承辅助平台(V2.5)、统计分析软件(IBM SPSS V20.)和Excel(Microsoft Office 2016)建立基础数据库,对组方用药(或配伍用药)与治疗病证进行频数统计、关联规则分析等数据挖掘。结果:按照纳入与排除标准进行处方筛选,收集含佛手临床处方共458首,涉及中药388味,用药总频数达6199次,其中佛手核心配伍药材(>130次)为茯苓(222次)、白术(217次)、白芍(196次)、柴胡(159次)、陈皮(142次)5味;选取与佛手配伍频数>49次的药材进行分类统计,其中包括药材34味,累计出现频数为3131次,占总频数的50.51%,以补气药、行气药、补血药、利水消肿药、消食药、活血止痛药为主;佛手配伍药材药性主要为温、寒、平,药味主要以苦、甘、辛味居多,主要归脾、肝、胃、肺经。含佛手临床处方配伍药材关联规则分析,常用药物组合有14组,核心药物组合为茯苓-佛手、白术-佛手、白芍-佛手、柴胡-佛手、白术-茯苓-佛手、陈皮-佛手。含佛手临床处方主治病证共52种,可分至11类中医病证类型,筛选出其中最具有代表性的“脾胃系病证”“气血津液病证”“妇科病证”3类高频主治中医病证类型进行关联规则分析,在治疗脾胃系病证时核心配伍药物为白术、茯苓、白芍、柴胡、陈皮、半夏,得到常用配伍药物组合共有25种,包括2联药物组合16种、3联药物组合9种;在治疗气血津液病证时核心配伍药物为茯苓、白芍、白术、黄芪、麦芽、柴胡,得到常用配伍药物组合共有23种,包括2联药物组合17种、3联药物组合5种、4联药物组合1种;在治疗妇科病证时核心配伍药物为白术、白芍、当归、黄芪、香附、茯苓,得到常用�Objective:To reveal the medication rules of the clinical prescriptions containing Citri Sarcodactylis Fructus,and to provide a basis for the modern clinical application of Citri Sarcodactylis Fructus,the development of health products and the research and development of new drugs.Method:The clinical prescriptions containing Citri Sarcodactylis Fructus were retrieved from CNKI,Wanfang Data,and VIP,and then a basic database of prescriptions was established via the traditional Chinese medicine inheritance auxiliary platform(V2.5),IBM SPSS V20,and Excel(Microsoft Office 2016).The frequency and association rules of the medicines in prescriptions(compatible medicines)and the corresponding syndromes were then mined.Result:The prescriptions were screened according to the inclusion and exclusion criteria.A total of 458 clinical prescriptions containing Citri Sarcodactylis Fructus were collected,involving 388 Chinese medicines,and the total frequency of medicines reached 6199.The core compatible medicines(frequency>130)of Citri Sarcodactylis Fructus included Poria(frequency of 222),Atractylodis Macrocephalae Rhizoma(217),Paeoniae Radix Alba(196),Bupleuri Radix(159),and Citri Reticulatae Pericarpium(142).The Citri Sarcodactylis Fructus-compatible medicines with frequency>49 were selected for further analysis,which included 34 medicines with the cumulative frequency of 3131(50.51%of the total frequency).These medicines mainly have the functions of tonifying Qi,invigorating Qi,tonifying blood,alleviating edema and promoting urination,promoting digestion,and activating blood and relieving pain.They are mainly warm,cold,or mildnatured,taste bitter,sweet,or acrid,and have the tropism in the spleen,liver,stomach,or lung meridians.The association rule analysis demonstrated that 14 medicine combinations were commonly used,and the core combinations were Poria-Citri Sarcodactylis Fructus,Atractylodis Macrocephalae Rhizoma-Citri Sarcodactylis Fructus,Paeoniae Radix Alba-Citri Sarcodactylis Fructus,Bupleuri Radix-Citri Sarcodactylis Fr

关 键 词：佛手 数据挖掘 临床处方 用药规律 中医传承辅助平台 

分 类 号：R285[医药卫生—中药学] R289[医药卫生—中医学]