“心梗-心衰”疾病演变过程概述与疾病动态分子网络研究进展  

Research Progress of Disease Developmental Process and Disease Dynamic Molecular Network Construction of"Myocardial Infarction-heart Failure"

作　　者：唐璇 席玉婕 郭非非 杨洪军[3] TANG Xuan;XI Yu-jie;GUO Fei-fei;YANG Hong-jun(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Experimental Research Center,China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]中国中医科学院中药研究所,北京100700 [2]天津中医药大学,天津301617 [3]中国中医科学院医学实验中心,北京100700

出　　处：《中国实验方剂学杂志》2022年第8期255-264,共10页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家重点研发计划项目(2019YFC1708900);国家“重大新药创制”科技重大专项(2019ZX09201005)。

摘　　要：随着组学技术的发展,利用系统生物学技术构建疾病网络进而研究复杂疾病的方法已运用十分广泛。利用构建疾病网络的方法,模拟疾病的发生过程,挖掘复杂疾病的核心发展机制,进而预测疾病标志物并探究药物作用机制,这种基于疾病分子网络的机制探究模式为复杂疾病的预防与治疗提供了新思路。如今,心肌缺血导致的心肌梗死(以下简称"心梗")及心梗后心力衰竭(以下简称"心衰")的演变机制研究仍被重点关注,但"心梗-心衰"疾病分子网络的研究往往局限于某几个靶点和通路,尚不能全面系统地阐释疾病进程。基于此,笔者拟从病理生理层面概述"心梗-心衰"的典型生物学过程及相关优势疾病因子,并针对目前已建立的心系疾病及其他疾病的动态网络构建方法进行总结,根据心系疾病及其他疾病的动态分子网络构建方法对"心梗-心衰"动态网络的构建展开讨论,以期更加准确地理解"心梗-心衰"疾病演变过程,探究该疾病过程的动态分子网络对于疾病机制研究的重要性。With the development of omics technology,the construction of disease networks has been widely used in the study of complex diseases.It has been widely used to construct disease networks using systems biology technology to study complex diseases.The mechanism exploration model of disease molecular network which uses the method of constructing disease networks,simulates the occurrence of diseases,explores the core development mechanism of complex diseases,and then predicts biomarkers and exploits the mechanism of drug action provided many new thoughts for the prevention and treatment of complex diseases.Nowadays,the research on the mechanism of myocardial infarction caused by myocardial ischemia and heart failure after myocardial infarction is still very important.However,the research of the molecular network of myocardial infarction and heart failure diseases is usually limited to a few targets and pathways,so it is not able to comprehensively and systematically explain the disease process.Furthermore,authors outlined the typical biological process of"myocardial infarction-heart failure"and related targets from the pathophysiological level,and summarized the existing methods of constructing dynamic networks for heart diseases and other diseases.Based on the dynamic molecular network construction methods of cardiac diseases and other diseases,this paper discusses the construction of the dynamic molecular network of myocardial infarction and heart failure,in order to understand the evolution of myocardial infarction and heart failure more accurately and explore the importance of the dynamic molecular network of the disease process for the study of disease mechanism.

关 键 词：心肌梗死 心力衰竭 动态网络 病理生理过程 优势病种 生物标志物 基因表达 

分 类 号：R22[医药卫生—中医基础理论] R28[医药卫生—中医学]