原发性皮肤CD4^(+)小/中T细胞淋巴组织增生性疾病一例  

Primary cutaneous CD4^(+)small/medium T-cell lymphoproliferative disorder: a case report

作　　者：刘小琴 熊心猜[1] 李凤香 杨晓龙 LIU Xiaoqin;XIONG Xincai;LI Fengxiang;YANG Xiaolong(Department of Dermatology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China)

机构地区：[1]川北医学院附属医院皮肤科,四川南充637000

出　　处：《中国麻风皮肤病杂志》2022年第6期398-400,共3页China Journal of Leprosy and Skin Diseases

摘　　要：患者,女,55岁。右耳后结节半年。皮损组织病理示:真皮组织内、皮肤附属器周围见大量中等大小淋巴细胞浸润,细胞轻度异型,背景可见小淋巴细胞和组织细胞。免疫组化提示:CD4(+)、CD8(+,少数细胞)、CD20(+)、CD3(+)、CD2(+)、CD79a散在(+)、CD5(+)、CD7(+)、Ki-67(+,<5%)。TCRG基因重排检测在目标条带范围内查见克隆性扩增峰。诊断:原发性皮肤CD4;小/中T淋巴组织增生性疾病,予以局部手术切除。A 55-year-old female presented with nodule behind the right ear for half a year. Skin biopsy revealed that a large number of medium-size lymphocytes infiltrated in the dermis and around the skin appendages, with mild atypia, and small lymphocytes and histological cells were seen. Immunohistochemistry examination showed that CD4(+), CD8(+, a few cells), CD2(+), CD20(+), CD3(+), CD79 a scattered(+), CD5(+), CD7(+), Ki-67(+, < 5%). The clonal amplification peak was found in the target band by TCRG gene rearrangement detection. The diagnosis of primary cutaneous CD4;small/medium T-cell lymphoproliferative disorder was made.

关 键 词：淋巴组织增生性疾病 原发性皮肤淋巴瘤 T细胞淋巴瘤 CD4^(+) 

分 类 号：R739.5[医药卫生—肿瘤]