Progress and Challenge in Computational Identification of Influenza Virus Reassortment  

作　　者：Xiao Ding Luyao Qin Jing Meng Yousong Peng Aiping Wu Taijiao Jiang 

机构地区：[1]Center for Systems Medicine,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100005,China [2]College of Biology,Hunan Provincial Key Laboratory of Medical Virology,Hunan University,Changsha 410082,China [3]Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory),Guangzhou 510005,China [4]Suzhou Institute of Systems Medicine,Suzhou,Jiangsu 215123,China

出　　处：《Virologica Sinica》2021年第6期1273-1283,共11页中国病毒学（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(31801101 to X.D.,31671371,32070678 to T.J.);the CAMS Initiative for Innovative Medicine(CAMS-I2M,2016-I2M-1-005,2020-I2M-2-003 to T.J.)。

摘　　要：Genomic reassortment is an important evolutionary mechanism for influenza viruses.In this process,the novel viruses acquire new characteristics by the exchange of the intact gene segments among multiple influenza virus genomes,which may cause flu endemics and epidemics within or even across hosts.Due to the safety and ethical limitations of the experimental studies on influenza virus reassortment,numerous computational researches on the influenza virus reassortment have been done with the explosion of the influenza virus genomic data.A great amount of computational methods and bioinformatics databases were developed to facilitate the identification of influenza virus reassortments.In this review,we summarized the progress and challenge of the bioinformatics research on influenza virus reassortment,which can guide the researchers to investigate the influenza virus reassortment events reasonably and provide valuable insight to develop the related computational identification tools.

关 键 词：Influenza virus REASSORTMENT BIOINFORMATICS IDENTIFICATION DATABASE 

分 类 号：R373.13[医药卫生—病原生物学]