ASPM在恶性肿瘤中的研究进展  

Research Progress of ASPM in Malignant Tumors

作　　者：杨开炎 黄兰诚 林钻平 唐凤珠[1] YANG Kaiyan;HUANG Lancheng;LIN Zuanping;TANG Fengzhu(Department of Otorhinolaryngology,Head and Neck,People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530000,China;Department of Otorhinolaryngology,Head and Neck Surgery,Baise People′s Hospital,Baise 533000,China)

机构地区：[1]广西壮族自治区人民医院耳鼻咽喉头颈科,南宁530000 [2]百色市人民医院耳鼻咽喉头颈外科,广西百色533000

出　　处：《医学综述》2022年第7期1322-1326,共5页Medical Recapitulate

基　　金：国家自然科学基金(82060190);广西重点研发计划项目(桂科AB17292089);广西医疗卫生适宜技术开发与推广应用项目(S2017078);广西壮族自治区卫生健康委员会自筹经费科研课题(Z20211109);广西科技基地和人才专项(桂科AD20297069)。

摘　　要：异常纺锤体样小头畸形相关蛋白(ASPM)基因是最常见的常染色体隐性小头畸形突变基因。其主要功能包括正确引导有丝分裂中纺锤体向两极运动以及维持细胞质的均等分裂,在有丝分裂纺锤体调节和有丝分裂过程的协调中发挥作用,并调控细胞周期进展。ASPM在各种恶性肿瘤组织高表达,影响恶性肿瘤的发生、发展及预后。同时,ASPM还参与肿瘤细胞DNA双链断裂修复,与肿瘤细胞化疗或放疗耐药性有关。目前ASPM在人类恶性肿瘤中的作用机制尚未明确,未来深入研究ASPM与肿瘤信号通路的关系及其作为肿瘤治疗靶标的作用,可为恶性肿瘤的治疗提供新思路。Abnormal spindle-like microcephaly-associated protein(ASPM)gene is the most common autosomal recessive microcephaly mutant gene.Its main function is to correctly guide the movement of the spindle to the poles in mitosis and maintain the equal division of cytoplasm,playing a role in the regulation of the mitotic spindle and the coordination of the mitotic process,and regulating the progress of the cell cycle.ASPM is highly expressed in various malignant tumor tissues,and affects their occurrence,development and prognosis.ASPM is also involved in the repair of tumor cell DNA double-strand breaks,and is related to tumor cell resistance to chemotherapy or radiotherapy.At present,the mechanism of ASPM in human malignant tumors is not clear.In the future,in-depth study of the relationship between ASPM and tumor signaling pathways and its role as tumor treatment target can provide new ideas for the treatment of malignant tumors.

关 键 词：恶性肿瘤 异常纺锤体样小头畸形相关蛋白 细胞周期 信号通路 

分 类 号：R730.2[医药卫生—肿瘤]